Lectures related to Mapping Local Proteome Responsivity

Proteome Mapping & Electrophile Responsivity

Explores proteome mapping, electrophile responsivity, precision medicine, and spatial omics technologies in drug target identification.

Quantitative Proteome Profiling: Chemical Target Identification

Explores quantitative proteome profiling for drug target identification through activity-based protein profiling and advanced mass spectrometry techniques.

Identifying Drug Targets with Thermal-Shift Profiling

Showcases correlations between different organs' thermal profiles to identify drug targets.

Drug Target Discovery: Thermal Shift Profiling

Covers drug target discovery through stability shifts and proteomics with isobaric tags.

Introduction: small molecule drugs for cancer

Introduces small molecule drugs for cancer treatment, covering drug discovery, mechanisms of action, and historical development of anti-cancer agents.

Tissue Patterning: Engineering Complex Organ Patterns

Explores tissue patterning, focusing on complex organ patterns through cell interactions and morphogen gradients.

Drug Discovery: Computational Approaches

Explores the EXSCALATE4COV project, focusing on computational drug discovery for COVID-19 treatments and the collaboration between academia and industry.

Activity-based Protein Profiling: Druggable Sites Identification

Explores Activity-based Protein Profiling for druggable site identification and strategies to minimize off-target reactivity of covalent inhibitors.

Precision Electrophile Signaling: Tools for Unconventional Codes

Presents T-REX, a method for studying electrophile signaling in vivo and its applications in live cells and animal models.

Infectious Diseases: Small Molecule Drugs

Explores small molecule drugs for infectious diseases, covering global mortality rates, viral and bacterial injuries, antiviral and antibacterial agents, and the development of COX2 inhibitors.

Kidney-on-a-Chip Technologies

Covers the state-of-the-art kidney-on-chip technologies aiming to facilitate pharmaceutical research and eliminate animal testing.

Organoids: Model Systems in Tissue Engineering

Explores the development and applications of organoids in tissue engineering and disease modeling using miniature in vitro constructs.

Fine-grained Patterning: Lateral Inhibition

Explores the development of the vulva in C. elegans and the intricate signaling pathways involved in inducing and inhibiting gene expression.

Protein Reactivity and Chemical Probes

Explores protein reactivity, chemical probes, and quantitative chemoproteomics in biological systems.

Radiotherapy: Basics & Classical Methods

Explores the basics of radiotherapy, including biological principles, types, techniques, and classical methods used in fighting cancer.

Interrogating SAR in Medical Chemistry Log in to Mediaspace to watch this video

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Chemical Biology: High-Throughput and High-Content Screening Log in to Mediaspace to watch this video

Covers Chemical Biology, high-throughput screening, RNA interference, CRISPR-Cas9, and organoid differentiation for drug discovery.

Fragment-Based Drug Discovery: Concepts & Technologies Log in to Mediaspace to watch this video

Covers the concepts and technologies of fragment-based drug discovery, hit identification methods, and its application in target-based drug discovery.

Chemical Biology Toolsets: Enzyme Inhibition and Metabolic Signaling Log in to Mediaspace to watch this video

Explores enzyme inhibition, metabolic signaling, glycolysis, and isotopic tracing in central carbon metabolism.

Chemical Biology Toolsets Log in to Mediaspace to watch this video

Explores advanced chemical biology toolsets for target identification and enrichment, including stable isotope labeling and competitive ABPP.