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Course

BIO-471: Cancer biology I

Lectures in this course (30)

PhD Programs at EPFL

Covers PhD programs at EPFL, including selection procedures, research areas, and support for students.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, DNA repair, telomeres, viruses, cell cycle, stem cells, metastasis, and genetic instability.

Altered Metabolism in Cancer: Warburg Effect and MYC Regulation

Explores altered cancer metabolism, MYC regulation, Rb and p53 pathways, AKT re-activation, and protein-protein interactions.

Understanding Cancer Genomics

Explores the revolution in cancer genomics, sequencing technologies, gene expression influence, and sequencing methods.

Cancer Genomics: Comprehensive Molecular Characterization and Evolution

Explores comprehensive genomic characterization, mutual exclusivity, and cancer evolution.

Understanding Cancer Therapies

Explores cancer therapies, including chemotherapies and targeted therapies, discussing mechanisms of action, limitations, and the development of resistance.

B-Cell Receptor Signaling in Lymphoma and Leukemia

Explores B-cell receptor signaling in lymphoma and leukemia, drug resistance mechanisms, CRISPR/Cas9 gene editing, mTOR inhibitors, cell cycle inhibition, and undruggable oncogenes.

Immunotherapy: Antibody-Based Strategies

Explores immunotherapy strategies, including T cell trafficking, antibody-based treatments, and genetically engineered T-cells for cancer therapy.

Cancer Immunotherapies: History, Players, and Mechanisms

Explores the history, mechanisms, and players of cancer immunotherapies, including immune evasion strategies and the role of MHC in antigen presentation.

Cancer Immunotherapies: Mechanisms and Applications

Explores the mechanisms and applications of cancer immunotherapies, including antibody-based treatments and genetically engineered T-cells.

Telomeres and Cancer

Explores telomeres' crucial role in cancer biology, covering telomerase, replication problems, ALT pathway, and TERRA functions.

Telomere Syndromes: Molecular Mechanisms and Disease Implications

Explores telomere syndromes, telomerase expression, end replication problems, telomere length during aging, defects in telomerase genes, and mouse models.

Cancer Biology: p53 and DNA Repair

Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.

DNA Repair Mechanisms

Explores DNA repair mechanisms, focusing on BER and NER, cellular responses to DNA damage, and genetic disorders impacting DNA repair and cancer susceptibility.

DNA Damage Response

Explores experiments on DNA damage response, protein-DNA interactions, and cell cycle consequences.

Genomic Alterations in Cancer

Explores genetic and epigenetic changes in cancer, including mutations, chromosomal alterations, and high-throughput measurement methods.

DNA Methylation and Histone Modifications

Explores DNA methylation, CpG islands, histone modifications, EZH2 mutations, microRNAs in cancer, and genomic alterations in microRNAs.

Altered Pathways in Cancer: Signaling Cascades and Mutations

Explores cancer pathways, major signaling cascades, and mutations in RAS and BRAF genes.

Cancer Biology: Hallmarks and Mechanisms

Covers the hallmarks of cancer, oncogenes, tumor suppressor genes, metastasis, and genetic alterations driving tumorigenesis.

BRCA2 Mutations: Mechanisms and Implications

Explores BRCA2 mutations, DNA repair mechanisms, and therapeutic implications for BRCA mutant cancers.