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Concept

Drug

Related lectures (29)

Machine Learning Approaches to Human Disease Log in to Mediaspace to watch this video

Explores the impact of machine learning in understanding human diseases, focusing on historical significance, natural products discovery, and challenges in designer drugs.

Kinase Inhibitors: Types and Mechanisms Log in to Mediaspace to watch this video

Explores kinase inhibitors, enzyme inhibition methods, transition state analog drugs, and the significance of covalent drugs in pharmaceutical research.

Enzyme Inhibition Mechanisms Log in to Mediaspace to watch this video

Covers enzyme inhibition mechanisms, drug modes of action, targeted protein degradation using PROTACs, and the bump-hole method for protein-ligand engineering.

Pharmacokinetic & Pharmacodynamic Evaluations Log in to Mediaspace to watch this video

Covers the principles of pharmacokinetics and pharmacodynamics, including drug exposure-response relationships.

Machine Learning-Guided Treatment Discovery Log in to Mediaspace to watch this video

Explores personalized medicine, machine learning for treatment prediction, and challenges in traditional algorithms.

Pharmacokinetic & Pharmacodynamic Studies Log in to Mediaspace to watch this video

Discusses the importance of assessing PK/PD relationships in drug development and the use of multiple PD biomarkers.

Engineering brain activity patterns for therapeutics Log in to Mediaspace to watch this video

Discusses correcting aberrant brain-wide activity patterns using distinct network motifs and neuromodulators.

Drug-Induced Liver Injury (DILI): Mechanisms and Mitigation Log in to Mediaspace to watch this video

Delves into Drug-Induced Liver Injury (DILI) mechanisms, metabolism, and mitigation strategies in drug development.

Preclinical Animal Models: Selection & Rationale Log in to Mediaspace to watch this video

Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.