Lecture

Pharmacokinetics: Drug Excretion and Transporters

Graph Chat

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

Description

This lecture covers the pathways of drug excretion, focusing on the renal blood circulation, kidney structure-function, and the role of the proximal tubule in drug reabsorption and secretion. It also discusses the influence of factors like pH and urine flow rate on drug elimination, as well as the involvement of transporters in drug absorption and excretion.

Official source

Ontological neighbourhood

Health sciences

Urology: Topics in urology

Related concepts (32)

Renal physiology

Renal physiology (Latin rēnēs, "kidneys") is the study of the physiology of the kidney. This encompasses all functions of the kidney, including maintenance of acid-base balance; regulation of fluid balance; regulation of sodium, potassium, and other electrolytes; clearance of toxins; absorption of glucose, amino acids, and other small molecules; regulation of blood pressure; production of various hormones, such as erythropoietin; and activation of vitamin D.

Clearance (pharmacology)

In pharmacology, clearance is a pharmacokinetic measurement of the volume of plasma from which a substance is completely removed per unit time. Usually, clearance is measured in L/h or mL/min. The quantity reflects the rate of drug elimination divided by plasma concentration. Excretion, on the other hand, is a measurement of the amount of a substance removed from the body per unit time (e.g., mg/min, μg/min, etc.). While clearance and excretion of a substance are related, they are not the same thing.

Assessment of kidney function

Assessment of kidney function occurs in different ways, using the presence of symptoms and signs, as well as measurements using urine tests, blood tests, and medical imaging. Functions of a healthy kidney include maintaining a person's fluid balance, maintaining an acid-base balance; regulating electrolytes including sodium, potassium, and other electrolytes; clearing toxins; regulating blood pressure; and regulating hormones, such as erythropoietin; and activation of vitamin D.

Kidney

In humans, the kidneys are two reddish-brown bean-shaped blood-filtering organs that are a multilobar multipapillary form of mammalian kidney, usually without signs of external lobulation. They are located on the left and right in the retroperitoneal space, and in adult humans are about in length. They receive blood from the paired renal arteries; blood exits into the paired renal veins. Each kidney is attached to a ureter, a tube that carries excreted urine to the bladder.

Urinary system

The urinary system, also known as the urinary tract or renal system, consists of the kidneys, ureters, bladder, and the urethra. The purpose of the urinary system is to eliminate waste from the body, regulate blood volume and blood pressure, control levels of electrolytes and metabolites, and regulate blood pH. The urinary tract is the body's drainage system for the eventual removal of urine. The kidneys have an extensive blood supply via the renal arteries which leave the kidneys via the renal vein.

Related lectures (64)

Abdomen Anatomy: Viscera, Peritoneum, Digestive System, Urinary System

Explores the anatomy of the abdomen, digestive system, and urinary system.

Renal Anatomy: Structure and Function

Explores the anatomy of the kidney, including its structure and vascularization.

Abdominal Viscera Anatomy

Covers the anatomy of abdominal viscera, focusing on the stomach's detailed structure and function.

Abdomen Anatomy: Viscera, Peritoneum, Digestive and Urinary Systems

Covers the anatomy of the abdomen, digestive and urinary systems.

Renal Nephron Anatomy