Satyam TiwariExpertise
Protein biophysics, Protein Engineering, Chaperone biology, Protein folding, Protein misfolding diseases , Statistical Data Analysis, Cell molecular biolgy
Mission
I employ biophysics and protein biochemistry to address and comprehend protein misfolding and aggregation. The goal is to design molecular chaperone-based disaggregases (protein drugs, biotherapeutics) targeted at disease-specific protein aggregates. I am currently investigating TDP-43 misfolding and amyloid formation (this protein aggr
Johan AuwerxJohan Auwerx is Professor at the École Polytechnique Fédérale in Lausanne, Switzerland, where he occupies the Nestle Chair in Energy Metabolism. Dr. Auwerx has been using molecular physiology and systems genetics to understand metabolism in health, aging and disease. Much of his work focused on understanding how diet, exercise and hormones control metabolism through changing the expression of genes by altering the activity of transcription factors and their associated cofactors. His work was instrumental for the development of agonists of nuclear receptors - a particular class of transcription factors - into drugs, which now are used to treat high blood lipid levels, fatty liver, and type 2 diabetes. Dr. Auwerx was amongst the first to recognize that transcriptional cofactors, which fine-tune the activity of transcription factors, act as energy sensors/effectors that influence metabolic homeostasis. His research validated these cofactors as novel targets to treat metabolic diseases, and spurred the clinical use of natural compounds, such as resveratrol, as modulators of these cofactor pathways.
Johan Auwerx was elected as a member of EMBO in 2003 and is the recipient of a dozen of international scientific prizes, including the Danone International Nutrition Award, the Oskar Minkowski Prize, and the Morgagni Gold Medal. His work is highly cited by his peers with a h-factor of over 100. He is an editorial board member of several journals, including Cell Metabolism, Molecular Systems Biology, The EMBO Journal, Journal of Cell Biology, Cell, and Science. Dr. Auwerx co-founded a handful of biotech companies, including Carex, PhytoDia, and most recently Mitobridge, and has served on several scientific advisory boards.
Dr. Auwerx received both his MD and PhD in Molecular Endocrinology at the Katholieke Universiteit in Leuven, Belgium. He was a post-doctoral research fellow in the Departments of Medicine and Genetics of the University of Washington in Seattle.
Paul Joseph DysonPaul Dyson joined the Institute of Chemical Sciences and Engineering at the EPFL in 2002 where he heads the Laboratory of Organometallic and Medicinal Chemistry and between 2008 and 2016 chaired the Institute. He has won several prizes including the Werner Prize of the Swiss Chemical Society in 2004, the Award for Outstanding Achievements in Bioorganometallic Chemistry in 2010, the Centennial Luigi Sacconi Medal of the Italian Chemical Society in 2011, the Bioinorganic Chemistry Award of the Royal Society of Chemistry in 2015, the European Sustainable Chemistry Award of the European Chemical Society in 2018 and the Green Chemistry Award from the Royal Society of Chemistry in 2020. He is also a Clarivate Highly Cited Researcher and has an H-index >110 (web of science and google scholar). He was elected a Fellow of the Royal Society of Chemistry in 2010, a Fellow of the European Academy of Science in 2019 and a life-long fellow of the American Association for the Advancement of Science in 2020. Over the years he has held visiting professorships at the University of Bourgogne, University of Pierre et Marie Curie, University of Vienna, University of Rome Tor Vergara, Chimie Paristech and Shangai Jiao Tong University.Since 2016 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation.Between 2016-2021 he has been Member of the Council of the Division of Mathematics, Natural and Engineering Sciences at the Swiss National Science Foundation. In 2021 he was appointed Dean of the Faculty of Basic Sciences.
Harm-Anton KlokExpertise
Polymer design at nanoscaleBiologically-inspired polymers
Mission
Research at the Laboratory of Polymer (LP) focuses on the development of novel advanced polymeric materials with potential applications in optics, electronics or medicine. The philosophy is that precise control over nanoscale structure is an important prerequisite to tailor polymer properties. To this end, a “bottom-up” approach is followed, which starts with designing a new material at the molecular level, in order to be able to pr
Hans Peter HerzigDr. Hans Peter Herzig is Professor at the Ecole Polytechnique Fédérale de Lausanne (EPFL) and Past President of the European Optical Society (EOS). His current research interests include refractive and diffractive micro-optics, nano-scale optics and optical MEMS.
Hans Peter Herzig received his diploma in physics from the Swiss Federal Institute of Technology in Zürich, Switzerland, in 1978. From 1978 to 1982 he was a scientist with the Optics Development Department of Kern in Aarau, Switzerland, working in lens design and optical testing. In 1983, he became a graduate research assistant with the Applied Optics Group at the Institute of Microtechnology of the University of Neuchâtel, Switzerland, working in the field of holographic optical elements. In 1987, he received his PhD degree in optics. From 1989 to 2001 he was head of the micro-optics research group in Neuchâtel. From 2002 to 2008 he was a full professor and head of the Applied Optics Laboratory at the University of Neuchâtel. Professor Herzig joined the faculty at EPFL in January 2009.
He is member of OSA, IEEE Photonics Society and Fellow of EOS. 2009-2010 he was President of the European Optical Society (EOS), 2001-2009 Vice-President of the Swiss Society of Optics and Microscopy and 2012-2014 Vice-President of ICO. Dr. Herzig is in the editorial board of different scientific journals (JM3, Optical Review, JEOS). He served as Conference Chairman for international conferences of EOS, IEE, IEEE/LEOS, OSA and SPIE; and as Guest Editor of three special issues of IEEE, OSA journals. He is editor of a well-known book on micro-optics (published in English and Chinese), author of 14 book chapters, over 150 peer reviewed articles and 300 conference proceedings.
Andrzej KulikExpertise
Experimental Biophysics,nanomechanics,nanomanipulation in 2D and 3D,nanotribology,Atomic Force Microscopy,Optical Tweezers,Photonic Force Microscopy,nano Infrared Spectroscopy (nanoIR),Acoustics,Ultrasound,
Expertise
Experimental Biophysics,nanomechanics,nanomanipulation in 2D and 3D,nanotribology,Atomic Force Microscopy,Optical Tweezers,Photonic Force Microscopy,nano Infrared Spectroscopy (nanoIR),Acoustics,Ultrasound,
Henning Paul-Julius StahlbergMission
We use high-resolution cryo-electron microscopy to study neurodegeneration and other protein systems. We also develop novel imaging technology in the areas of electron microscopy hardware and applications, sample preparation, data collection schemes, and data analysis software systems. The Stahlberg group is supported by the University of Lausanne, Faculty of Medicine and Biology, and by the EPFL, Faculty of Basic Sciences, Physics Institute. The LBEM is a research laboratory of both UNIL and EPFL.
Luciano Andres AbriataExpertise
Protein NMRNMR of paramagnetic systemsMetalloproteinsBiomolecular SpectroscopyStructural BiologyStructural BioinformaticsMolecular Modeling
ResearchPapers Link to Google Scholar
Teaching & PhD Courses Basic and advanced NMR - Level 1 A (EPFL) CH-601(x) Basic theoretical and experimental aspects of NMR will be taught. Students will be familarized with modern NMR spectrometers. Basic and advanced NMR - Level 2 (EPFL) CH-703 The goal is to give a sound theoretical an
Camille Véronique Bernadette GoemansCamille's research focuses on understanding how antibiotics and non-antibiotic drugs affect the diverse bacteria from the human gut microbiota and how they contribute to dysbiosis and the development of antibiotic resistance. To achieve this goal, she combines systems approaches with molecular microbiology, bacterial genetics and biochemistry.She obtained her Bachelor's and Master's degrees in Biomedical Sciences from the UCLouvain, Belgium, after which she completed her PhD (FRIA national fellowship) at th
Nicolas ThomäTeaching & PhD PhD Students David Domjan, Pierre Alexander Miranda Herrera, Laurin Tim Kanis, Alessandro Minafra, Pau Reolid Coll Courses Practical - Thomä Lab BIO-624 Expression and purification of recombinant proteins are key methods in our lab studying protein machines on a structural level and ways in which they can be reprogrammed by small molecules. In the course, we will express and purify proteins and biophysically characterise them. Trends in chemical biology and drug discovery
Francesco StellacciFrancesco Stellacci graduated in Materials Engineering at the Politecnico di Milano in 1998 with a thesis on photochromic polymers with Prof. Giuseppe Zerbi and Mariacarla Gallazzi. In 1999 he moved to the Chemistry Department of the University of Arizona for as a post-doc in the group of Joe Perry in close collaboration with the group of Seth Marder. In 2002 he moved to the Department of Materials Science and Engineering at the Massachusetts Institute of Technology as an assistant professor. He was then promoted to associate without (2006) and with tenure (2009). In 2010 he moved to the Institute of Materials at EPFL as a full Professor. He holds the Alcan EP Chair. Francesco was one of the recipients of the Technology Review TR35 "35 Innovator under 35" award in 2005, and the Popular Science Magazine "Brilliant 10" award in 2007. He has been a Packard Fellow starting 2005.
Quy Ong KhacExpertise
Nanoparticle characterizationSurface and interface scienceAnalytical ultracentrifugationCryogenic electron tomographyScanning tunneling microscopy
Current Work
Cryogenic Transmission Electron Tomography (Cryo-ET): Developed Cryo-ET methods as quantitative thermodynamic tools. Studied interaction potentials and other thermodynamic properties of nanoparticles and proteins. Key publications: Ong Q. et al. Materials Horizons, 2022Ekaterina P., Ong, Q. et al. ACS Nano, 2026Analytical Ultracentrifugatio
Laure MeninExpertise
Mass spectrometryLC-MS / GC-MSBiochemistryProteomicsToxinologyDrug discovery
Teaching & PhD Courses Mass spectrometry, principles and applications CH-728 The goal is to provide students with a complete overview of the principles and key applications of modern mass spectrometry and meet the current practical demand of EPFL researchers to improve structural analsis of molecules. Numerous instrumental aspects of mass spectrometry are described.
Christian HeinisTeaching & PhD PhD Students Thomas Julien Denis Emel, Alessandro Scapozza, Nathan Moïse De Sadeleer, Florian Handel, Hugo André Clerc, Frédéric Brantschen, Grégoire Menoud, Ines Michrafy, Jonathan Schmitt, Laura Elena Massaad Past EPFL PhD Students Jeremy Touati, Shiyu Chen, Sophie Venet-Bonnot, Lisa Pollaro, Inmaculada Rentero Rebollo, Philippe Diderich, Charlotte Urech-Varenne, Silvia Bellotto, Davide Bertoldo, Alessandro Zorzi, Camille Villequey, Jonas Alfred Karl Wilbs, Grigory Karateev, Vanessa Carle
Giovanni D'AngeloTeaching & PhD PhD Students Mélissa Ruiz, Gary Domeniconi, Irmak Kaysudu, Alessandro Valente, Surayyo Akramkhanova, Jean Andrea Maillat, Linda Wedemann, Manel Leila Nadia Boussouf, Jiayan Lin, Nika Gorsek, Christina Ulrich, William Daniel Chan-Ha Verdier Past EPFL PhD Students Laura Capolupo, Jaipreet Singh Loomba, Halima Hannah Emilie Schede Past EPFL PhD Students as codirector Muhammad Umair Anwar Courses Biological chemistry II BIO-213 Biochemistry is a key discipline in the Life Scienc
Patrick Daniel BarthProfessor Patrick Barth is Associate Professor at EPFL and Adjunct Associate Professor at Baylor College of Medicine, Houston, TX, USA. He received training in Physics, Chemistry and Biology (University of Paris, ENS) in France and performed his PhD at the Commissiariat a l'Energie Atomique in Saclay, France on structure/function studies of membrane proteins (photosystem I) using biochemical and biophysical experimental techniques. He carried out postdoctoral studies at University of California at Berkeley with Tom Alber on computational development for calculating protein electrostatics and designing de novo selective peptide inhibitors of cellular protein interactions. He then went to the University of Washington as a postdoctoral fellow and instructor in David Baker's laboratory to develop computational techniques in the software Rosetta for predicting and designing membrane protein structures. He started his independent career and received tenure at Baylor College of Medicine. He will continue at EPFL to marry computation and experiment for understanding the molecular determinants of signal transduction, as well as modeling and designing membrane proteins with novel functions for various synthetic biology and therapeutic applications.
Marcel DrabbelsDr. Marcel Drabbels studied experimental physics at the University of Nijmegen (the Netherlands) and in 1993 obtained his Ph.D. at that same university. He then moved to the University of California at Santa Barbara where he studied the dynamics of highly vibrationally excited molecules and developed a new detection technique to investigate the photodissociation of molecules. When he returned to the Netherlands in 1996 he joined the FOM Institute for Atomic and Molecular Physics in Amsterdam where he worked on the development of new types of infrared imaging and streak cameras. In 1997 Dr. Drabbels was awarded a fellowship of the Royal Dutch Academy of Sciences and he moved to the Free University of Amsterdam where he studied the collision dynamics of molecules and initiated photodissociation experiments using ultrafast lasers. In October 1998 he was appointed as senior scientist at the EPFL where he studies the spectroscopy and dynamics of nanoscale systems. In March 2021 he was promoted to titular professor.
Paolo De Los RiosPaolo De Los Rios earned his master in Electronic Engineering at the Turin Institute of Technology (Politecnico di Torino) in May 1993. In November 1993 he moved to Trieste, Italy, to enter the PhD program in Theoretical Condensed Matter Theory at the International School for Advanced Studies (SISSA/ISAS) where he obtained the PhD degree in October 1996 for his work on the statistical physics of disordered systems. After a one year postdoc at the Max-Planck Institute for the Physics of Complex Systems in Dresden, Germany, in November 1997 he moved to the University of Fribourg, Switzerland, to join the group of Prof. Yi-Cheng Zhang. There he has worked on various applications of statistical physics to complex systems. In September 2000 he has been appointed Assistant Professor in Statistical Physics of Living Matter and Complex Systems at the Institute of Theoretical Physics of the University of Lausanne, Switzerland. Since April 2010 he is Associate Professor at the Institute of Theoretical Physics of the Ecole Polytechnique Fédérale de Lausanne (EPFL), Switzerland.
