This article documents the chronology and epidemiology of SARS-CoV-2, the virus that causes the coronavirus disease 2019 (COVID-19) and is responsible for the COVID-19 pandemic, in April 2021. The first human cases of COVID-19 were identified in Wuhan, China, in December 2019. Chile surpasses 1 million COVID-19 cases. Malaysia has reported 1,178 new cases, bringing the total number to 346,678. 1,377 have recovered, bringing the total number of recoveries to 331,001. There are six deaths, bringing the death toll to 1,278. There are 14,399 active cases, with 163 in intensive care and 81 on ventilator support. New Zealand has reported five new cases, bringing the total number to 2,501 (2,145 confirmed and 356 probable). Nine people have recovered, bringing the total number of recoveries to 2,408. The death toll remains 26. There are 67 active cases, with one previously reported case being reclassified as under investigation. Singapore has reported 26 new imported cases, bringing the total to 60,407. There are 12 recoveries, bringing the total number of recoveries to 60,161. The death toll remains at 30. Ukraine has reported 17,569 new daily cases and a record 421 new daily deaths, bringing the total number to 1,691,737 and 33,246 respectively; a total of 1,323,083 patients have recovered. Malaysia has reported 1,294 new cases, bringing the total number to 347,972. There are 1,442 recoveries, bringing the total number of recoveries to 332,443. There are five deaths, bringing the death toll to 1,283. There are 14,246 active cases, with 168 in intensive care and 78 on ventilator support. Singapore has reported 43 new imported cases, bringing the total to 60,450. 15 people have recovered, bringing the total number of recoveries to 60,176. The death toll remains at 30. Ukraine has reported a record 19,893 new daily cases and a record 433 new daily deaths, bringing the total number to 1,711,630 and 33,679 respectively; a total of 1,333,370 patients have recovered. Canada surpasses 1 million COVID-19 cases.