Jérôme ChenalExpertise
Urban DesignUrban PlanningUrban ManagementPublic SpaceHousingDevelopment StudiesVisual Anthropology
Mission
Director of CEAT Director of Excellence in Africa Center Affiliate professor at UM6P
Teaching & PhD Past EPFL PhD Students Stéphanie Hasler, Rémi Jaligot, Armel Firmin Kemajou Mbianda, Martí Bosch Padrós, Andrea Salmi, Vitor Pessoa Colombo, Akuto Akpedze Konou, Rim Mrani Past EPFL PhD Students as codirector Marc Antoine Messer, Alexandre Rigal Courses Urban planning in the South PE
Simon Elias BibriExpertise
• Sustainable cities• Smarter eco-cities• Sustainable smart cities• Artificial Intelligence of Things (AIoT) • Generative Artificial Intelligence of Things (GAIoT)• Foundation Models (FMs) • Quantum Generative Artificial Intelligence (QGAI)• Urban Digital Twins (UDTs)• Urban Brain (UB) • Smart Circular Metabolism• Urban planning and design• Environmental sustainability and climate resilience• Sustainable smart energy• Sustainable smart transportation• Sustainable smart waste and water management•
Henry MarkramHenry Markram started a dual scientific and medical career at the University of Cape Town, in South Africa. His scientific work in the 80s revealed the polymodal receptive fields of pontomedullary reticular formation neurons in vivo and how acetylcholine re-organized these sensory maps.
He moved to Israel in 1988 and obtained his PhD at the Weizmann Institute where he discovered a link between acetylcholine and memory mechanisms by being the first to show that acetylcholine modulates the NMDA receptor in vitro studies, and thereby gates which synapses can undergo synaptic plasticity. He was also the first to characterize the electrical and anatomical properties of the cholinergic neurons in the medial septum diagonal band.
He carried out a first postdoctoral study as a Fulbright Scholar at the NIH, on the biophysics of ion channels on synaptic vesicles using sub-fractionation methods to isolate synaptic vesicles and patch-clamp recordings to characterize the ion channels. He carried out a second postdoctoral study at the Max Planck Institute, as a Minerva Fellow, where he discovered that individual action potentials propagating back into dendrites also cause pulsed influx of Ca2 into the dendrites and found that sub-threshold activity could also activated a low threshold Ca2 channel. He developed a model to show how different types of electrical activities can divert Ca2 to activate different intracellular targets depending on the speed of Ca2 influx an insight that helps explain how Ca2 acts as a universal second messenger. His most well known discovery is that of the millisecond watershed to judge the relevance of communication between neurons marked by the back-propagating action potential. This phenomenon is now called Spike Timing Dependent Plasticity (STDP), which many laboratories around the world have subsequently found in multiple brain regions and many theoreticians have incorporated as a learning rule. At the Max-Planck he also started exploring the micro-anatomical and physiological principles of the different neurons of the neocortex and of the mono-synaptic connections that they form - the first step towards a systematic reverse engineering of the neocortical microcircuitry to derive the blue prints of the cortical column in a manner that would allow computer model reconstruction.
He received a tenure track position at the Weizmann Institute where he continued the reverse engineering studies and also discovered a number of core principles of the structural and functional organization such as differential signaling onto different neurons, models of dynamic synapses with Misha Tsodyks, the computational functions of dynamic synapses, and how GABAergic neurons map onto interneurons and pyramidal neurons. A major contribution during this period was his discovery of Redistribution of Synaptic Efficacy (RSE), where he showed that co-activation of neurons does not only alter synaptic strength, but also the dynamics of transmission. At the Weizmann, he also found the tabula rasa principle which governs the random structural connectivity between pyramidal neurons and a non-random functional connectivity due to target selection. Markram also developed a novel computation framework with Wolfgang Maass to account for the impact of multiple time constants in neurons and synapses on information processing called liquid computing or high entropy computing.
In 2002, he was appointed Full professor at the EPFL where he founded and directed the Brain Mind Institute. During this time Markram continued his reverse engineering approaches and developed a series of new technologies to allow large-scale multi-neuron patch-clamp studies. Markrams lab discovered a novel microcircuit plasticity phenomenon where connections are formed and eliminated in a Darwinian manner as apposed to where synapses are strengthening or weakened as found for LTP. This was the first demonstration that neural circuits are constantly being re-wired and excitation can boost the rate of re-wiring.
At the EPFL he also completed the much of the reverse engineering studies on the neocortical microcircuitry, revealing deeper insight into the circuit design and built databases of the blue-print of the cortical column. In 2005 he used these databases to launched the Blue Brain Project. The BBP used IBMs most advanced supercomputers to reconstruct a detailed computer model of the neocortical column composed of 10000 neurons, more than 340 different types of neurons distributed according to a layer-based recipe of composition and interconnected with 30 million synapses (6 different types) according to synaptic mapping recipes. The Blue Brain team built dozens of applications that now allow automated reconstruction, simulation, visualization, analysis and calibration of detailed microcircuits. This Proof of Concept completed, Markrams lab has now set the agenda towards whole brain and molecular modeling.
With an in depth understanding of the neocortical microcircuit, Markram set a path to determine how the neocortex changes in Autism. He found hyper-reactivity due to hyper-connectivity in the circuitry and hyper-plasticity due to hyper-NMDA expression. Similar findings in the Amygdala together with behavioral evidence that the animal model of autism expressed hyper-fear led to the novel theory of Autism called the Intense World Syndrome proposed by Henry and Kamila Markram. The Intense World Syndrome claims that the brain of an Autist is hyper-sensitive and hyper-plastic which renders the world painfully intense and the brain overly autonomous. The theory is acquiring rapid recognition and many new studies have extended the findings to other brain regions and to other models of autism.
Markram aims to eventually build detailed computer models of brains of mammals to pioneer simulation-based research in the neuroscience which could serve to aggregate, integrate, unify and validate our knowledge of the brain and to use such a facility as a new tool to explore the emergence of intelligence and higher cognitive functions in the brain, and explore hypotheses of diseases as well as treatments.
Martine LapriseTeaching & PhD Courses Vers des villes bioclimatiques ? AR-688
Sophie LufkinFORMATION
2010 - Thèse de doctorat au sein de l'EDAR (Ecole doctorale Architecture, Ville, Histoire) sur la densification des friches ferroviaires, co-dirigée par les Prof. Inès Lamunière et Vincent Kaufmann
2005 - "Master of Art" en architecture, sous la direction des Prof. Patrick BERGER et Inès LAMUNIERE
2003 - Année d'échange à l'ETHZ
1999 - Entrée à l'EPFL, section architecture
1998 - Maturité type B, Collège Claparède, Genève
EXPERIENCE PROFESSIONNELLE
2010 - Architecte, Cheffe de projet chez LAR - Fernando Romero, México
2006 - Assistante de recherche à lEPFL au Laboratoire darchitecture et mobilité urbaine (LAMU), projet de recherche PNR54 "Densification des friches ferroviaires"
2005 - Architecte chez Devanthéry & Lamunière, Genève
2004 - Stage darchitecture, Eric Maria, Genève
2003 - Stage darchitecture, Sumi & Burkhalter, Zurich
2001 - Stage darchitecture, Devanthéry & Lamunière, Genève
RECOMPENSES ET BOURSES
2001 - Prix SIA Vaudoise pour le projet "Fondation Ella Maillart à Chandolin"
2005 - Prix de l'Association des diplômes A3-EPFL
2008 - Bourse Erna Hamburger
LANGUES
Français (maternelle), allemand et anglais (courantes), portugais (notions)
Paola ViganòTeaching & PhD PhD Students Noélie Marion Charlotte Lecoanet, Shyam Sunder Sirimalla Past EPFL PhD Students Roberto Sega, Antoine Vialle, Tommaso Pietropolli, Sylvie Tram Nguyen, Anna Karla De Almeida Milani, Elena Calafati, Flore Jeanne Marie Andrea Guichot Courses Hidden rivers PENS-219 Hidden Rivers aims at fulfilling the need for an interdisciplinary understanding of the problematics surrounding urban streams, through ecological, hydrological, and spatial relationships found in riversc