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Concept

Patch clamp

Related publications (26)

Detecting Road Obstacles by Erasing Them

Pascal Fua, Mathieu Salzmann, Sina Honari, Krzysztof Maciej Lis

Vehicles can encounter a myriad of obstacles on the road, and it is impossible to record them all beforehand to train a detector. Instead, we select image patches and inpaint them with the surrounding road texture, which tends to remove obstacles from thos ...

2024

Bodily implant microelectrode and bodily implant microelectrode fabrication method

Sandro Carrara, Diego Ghezzi, Gian Luca Barbruni

The present invention concerns a bodily implantable or probe device and microelectrode fabrication method comprising providing at least one silicon substrate including an electronic device or unit; providing, on a first side of the silicon substrate, at le ...

2024

Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

Carl Petersen, Sylvain Crochet, Aurélie Pala, Taro Kiritani, Célia Roxane Gasselin

Neocortical neurons can increasingly be divided into well-defined classes, but their activity patterns during quantified behavior remain to be fully determined. Here, we obtained membrane potential recordings from various classes of excitatory and inhibito ...

PUBLIC LIBRARY SCIENCE2023

Development of new volcano-shaped microelectrodes for single cell electrochemistry, electrophysiology and impedance studies

Nicolas Grégoire Maïno

Micro- nano-electrodes have demonstrated superior performances in measuring attenuated intracellular action potentials from electrogenic cell cultures compared to traditional multi-electrode arrays. Yet, the understanding of the critical electrode features ...

EPFL2023

Cortical cell assemblies and their underlying connectivity: an in silico study

Michael Reimann, András Ecker, Daniela Egas Santander, James Bryden Isbister, Sirio Bolaños Puchet

Recent developments in experimental techniques have enabled simultaneous recordings from thousands of neurons, enabling the study of functional cell assemblies. However, determining the patterns of synaptic connectivity giving rise to these assemblies rema ...

2024

A universal workflow for creation, validation and generalization of detailed neuronal models

Henry Markram, Werner Alfons Hilda Van Geit, Srikanth Ramaswamy, Alexis Arnaudon, Christian Andreas Rössert, Mustafa Anil Tuncel, Maria Reva, Tanguy Pierre Louis Damart, Darshan Mandge

Detailed single neuron modeling is widely used to study neuronal functions. While cellular and functional diversity across the mammalian cortex is vast, most of the available computational tools are dedicated to the reproduction of a small set of specific ...

Cambridge2023

Shoot-Through Protection for an IGCT-Based ZVS Resonant DC Transformer

Drazen Dujic, Jakub Kucka

IGCTs have successfully demonstrated to be well-suited devices for an application in medium-voltage dc transformers based on LLC resonant converter topology. This application enables unusually high switching frequencies in kHz range thanks to the zero-volt ...

2022

Computation Complexity Reduction Technique for Accurate Seizure Detection Implants

Alexandre Schmid, Keyvan Farhang Razi

An automatic seizure detection method from high-resolution intracranial-EEG (iEEG) signals is presented to minimize the computational complexity and realize real-time accurate seizure detection for biomedical implants. Complex signal processing on a large ...

IEEE2022

In-Cell Quantification of Drugs by Magic-Angle Spinning Dynamic Nuclear Polarization NMR

David Lyndon Emsley, Pierrick Berruyer, Andrea Bertarello

The determination of intracellular drug concentrations can provide a better understanding of the drug function and efficacy. Ideally, this should be performed nondestructively, with no modification of either the drug or the target, and with the capability ...

AMER CHEMICAL SOC2022

Influence of Oxidative Stress on Time-Resolved Oxygen Detection by [Ru(Phen)3]2+ In Vivo and In Vitro

Georges Wagnières, Veronika Huntosova

Detection of tissue and cell oxygenation is of high importance in fundamental biological and in many medical applications, particularly for monitoring dysfunction in the early stages of cancer. Measurements of the luminescence lifetimes of molecular probes ...

2021

Printed Iontophoretic‐Integrated Wearable Microfluidic Sweat‐Sensing Patch for On‐Demand Point‐Of‐Care Sweat Analysis

Danick Briand, Silvia Demuru, Brince Paul Kunnel

In recent years, wearable epidermal sweat sensors have received extensive attention owing to their great potential to provide personalized information on the health status of individuals at the molecular level. For on‐demand medical analysis of sweat in se ...

Wiley2021

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Data driven building of realistic neuron model using IBEA and CMA evolution strategies

Henry Markram, Werner Alfons Hilda Van Geit, Tanguy Pierre Louis Damart

Recently the building of large neuronal circuits from realistic neuron models has gained traction. This bottom-up approach relies on the accurate description of the primitive elements composing the brain such as neurons and astrocytes, that are then aggreg ...

ACM2020

Intracellular recording of cardiomyocyte action potentials with nanopatterned volcano-shaped microelectrodes

Benoît Xavier Emmanuel Desbiolles

Micro-nanotechnology based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recordings of excitable cells. However, electrode geometries alone have failed to produce a cell-electrode interface that is sufficiently ...

EPFL2020

Isogeometric analysis with C1 hierarchical functions on planar two-patch geometries

Rafael Vazquez Hernandez

Adaptive isogeometric methods for the solution of partial diifferential equations rely on the construction of locally refinable spline spaces. A simple and efficient way to obtain these spaces is to apply the multi-level construction of hierarchical spline ...

2020

Micropipette calibration by differential pressure measurements

Philippe Renaud, David Vincent Bonzon

The pipetting of small volumes, typically ranging between a few and one thousand microliters (mu l), is widely used in many laboratories and essentially relies on air displacement to aspirate and dispense the liquid contained in a small plastic tip. ...

IOP Publishing2019

Clamp-Tapering Increases the Quality Factor of Stressed Nanobeams

Tobias Kippenberg, Dalziel Joseph Wilson, Nils Johan Engelsen, Sergey Fedorov, Ryan Daniel Schilling, Amir Hossein Ghadimi, Alberto Beccari

Stressed nanomechanical resonators are known to have exceptionally high quality factors (Q) due to the dilution of intrinsic dissipation by stress. Typically, the amount of dissipation dilution and thus the resonator Q is limited by the high mode curvature ...

AMER CHEMICAL SOC2019

A stick-slip/inchworm hybrid rotary piezo motor based on a symmetric triangular driving mechanism

Dongdong Zheng

A stick-slip/inchworm hybrid rotary piezomotor based on a symmetric triangular driving mechanism, which can simultaneously achieve the benefits of both stick-slip and inchworm motors, was reported in this letter. It is based on the principle of stick-slip ...

2019

Microchannel-based technologies for nerve interfacing

Sandra Gribi

Biomedical technologies in neuroprosthetics are made to restore or replace functions from the nervous system, as well as alleviate pathological conditions. Peripheral nerve interfaces use neuromodulatory techniques to inhibit pain or depression, prevent ep ...

EPFL2019

Characterization of multi-channel intraneural stimulation in transradial amputees

Silvestro Micera, Stanisa Raspopovic, Fiorenzo Artoni, Ivo Strauss, Giacomo Valle, Francesco Maria Petrini, Pablo Garcia del Valle, Edoardo D'Anna

Although peripheral nerve stimulation using intraneural electrodes has been shown to be an effective and reliable solution to restore sensory feedback after hand loss, there have been no reports on the characterization of multi-channel stimulation. A deepe ...

Springer Nature2019