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Concept

Pre-replication complex

Related publications (29)

Effect of replica placement on the reliability of large scale data storage systems

Christina Fragouli, Xiao-Yu Hu, Vinodh Venkatesan

Replication is a widely used method to protect large- scale data storage systems from data loss when storage nodes fail. It is well known that the placement of replicas of the different data blocks across the nodes affects the time to rebuild. Several syst ...

2010

Interplay of DNA supercoiling and catenation during the segregation of sister duplexes

Guillaume Witz

The discrete regulation of supercoiling, catenation and knotting by DNA topoisomerases is well documented both in vivo and in vitro, but the interplay between them is still poorly understood. Here we studied DNA catenanes of bacterial plasmids arising as a ...

Oxford University Press2009

Phosphorylation of SAS-6 by ZYG-1 is critical for centriole formation in C. elegans embryos

Pierre Gönczy, Coralie Busso

Despite being essential for proper cell division, the mechanisms governing centrosome duplication are incompletely understood and represent an important open question in cell biology. Formation of a new centriole next to each existing one is critical for c ...

Cell Press - Elsevier2009

Homoeostasis between the GTPase Spg1p and its GAP in the regulation of cytokinesis in S. pombe

Viesturs Simanis, Andrea Krapp

Cytokinesis in Schizosaccharomyces pombe begins at mitotic entry, when the site of division is defined by formation of the contractile acto-myosin ring (CAR) at the cell cortex. Contraction of the CAR and formation of the division septum are triggered at t ...

2008

Chemical genetic analysis of the regulatory role of Cdc2p in the S. pombe septation initiation network

Viesturs Simanis, Andrea Krapp

The protein kinase Cdc2p is the master regulator of cell cycle progression in the fission yeast Schizosaccharomyces pombe. It is required both for entry into mitosis and for onset of DNA replication. Cdc2p must be inactivated to permit exit from mitosis, l ...

2008

Bottleneck genes and community structure in the cell cycle network of S-pombe

Paolo De Los Rios, Francesco Piazza

The identification of cell cycle-related genes is still a difficult task, even for organisms with relatively few genes such as the fission yeast. Several gene expression studies have been published on S. pombe showing similarities but also discrepancies in ...

Public Library of Science2007

The Schizosaccharomyces pombe septation initiation network (SIN) is required for spore formation in meiosis

Viesturs Simanis, Andrea Krapp

When nutrients are abundant, S. pombe cells grow as rods, dividing by fission after formation of a medially placed cell wall or division septum. Septum formation is triggered by a group of proteins, called the septation initiation network or SIN, that trig ...

2006

S. pombe FEAR protein orthologs are not required for release of Clp1/Flp1 phosphatase from the nucleolus during mitosis

Viesturs Simanis

Cdc14 family phosphatases are highly conserved regulators of cell-cycle progression. Two of the best studied members of this family are budding yeast Cdc14p and its fission yeast homolog Clp1p/Flp1p. The function of both Saccharomyces cerevisiae Cdc14p and ...

2006

New insight into the chemistry of allymetals

Eric Masson

The present thesis work provides new insight into the generation of allylmetal species and into their reactivity toward electrophiles. endo-Allylpotassiums are known to be more stable than their corresponding exo-isomers. The ring strain of methylenecycloa ...

EPFL2005