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Concept

Dose–response relationship

Related publications (27)

Microfluidic platforms for high-throughput mammalian cell printing, transfection, and dosage-dependent studies

Kristina Pan Woodruff

With the advent of high-throughput and genome-wide screening initiatives, there is a need for improved methods for cell-based assays. Current approaches require expensive equipment, rely on large-scale culturing formats not suited for small or rare sample ...

EPFL2017

Optimization of drug combinations using Feedback System Control

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser

We describe a protocol for the discovery of synergistic drug combinations for the treatment of disease. Synergistic drug combinations lead to the use of drugs at lower doses, which reduces side effects and can potentially lead to reduced drug resistance, w ...

Nature Publishing Group2016

Dose-response curve of a microfluidic magnetic bead-based surface coverage sandwich assay

Martinus Adela Maria Gijs, Thomas Lehnert, Matteo Cornaglia, Hüseyin Cumhur Tekin, Raphaël Etienne Jean Trouillon

Magnetic micro-and nanoparticles ('magnetic beads') have been used to advantage in many microfluidic devices for sensitive antigen (Ag) detection. Today, assays that use as read-out of the signal the number count of immobilized beads on a surface for quant ...

Elsevier2015

A streamlined search technology for identification of synergistic drug combinations

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

In vivo measurement of tissue oxygenation by time-resolved luminescence spectroscopy: advantageous properties of dichlorotris(1, 10-phenanthroline)-ruthenium(II) hydrate

Hubert van den Bergh, Georges Wagnières, Patrycja Nowak-Sliwinska, Matthieu Philippe Emmanuel Zellweger, Veronika Huntosova, Sandrine Gay

Measuring tissue oxygenation in vivo is of interest in fundamental biological as well as medical applications. One minimally invasive approach to assess the oxygen partial pressure in tissue (pO(2)) is to measure the oxygen-dependent luminescence lifetime ...

SPIE Society of Photo-optical Instrumentation Engineers2014

Systems Toxicology Approach to Understand the Kinetics of Benzo(a)pyrene Uptake, Biotransformation, and DNA Adduct Formation in a Liver Cell Model

Kristin Schirmer

Cell-based models are important for deriving mechanistic information about stress response pathways that have evolved to protect cells from toxic insult, such as exposure to environmental pollutants. One determinant of the stress response is the amount of ...

Amer Chemical Soc2014

Measured and Modeled Toxicokinetics in Cultured Fish Cells and Application to In Vitro - In Vivo Toxicity Extrapolation

Kristin Schirmer, Julita Maria Stadnicka-Michalak

Effect concentrations in the toxicity assessment of chemicals with fish and fish cells are generally based on external exposure concentrations. External concentrations as dose metrics, may, however, hamper interpretation and extrapolation of toxicological ...

Public Library Science2014