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ObjectiveTo identify factors associated with complementary and alternative medicine (CAM) use, investigate regional patterns, and examine whether CAM usage is associated with decreased expenditures in conventional medicine (CM).Participants and MethodsWe conducted a retrospective analysis of Swiss health insurance claims data from January 1, 2017, to December 31, 2021, including mandatory health insurance (MHI) and supplementary insurance (SI) schemes. We analyzed 816,080 person-years from 205,423 Swiss residents with dual coverage using 2-part multilevel models and geographic clustering analyses.ResultsCAM utilization differed markedly between schemes: 59% (481,176 of 816,080) used CAM (SI) while 2.2% (18,023) used CAM (MHI). Women had nearly double the odds of CAM (MHI) usage (adjusted odds ratio, 1.97; P