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Concept

Germ cell

Related publications (30)

Tissue- and sex-specific small RNAomes reveal sex differences in response to the environment

Pierre Gönczy, Laurent Keller, Alexandra Bezler, Frédéric Schütz

RNA interference (RNAi) related pathways are essential for germline development and fertility in metazoa and can contribute to inter- and trans-generational inheritance. In the nematode Caenorhabditis elegans, environmental double-stranded RNA provided by ...

2019

DUX is a non-essential synchronizer of zygotic genome activation

Didier Trono, Sandra Eloise Kjeldsen, Delphine Yvette L Grun, Sonia Verp, Alberto De Iaco

Some of the earliest transcripts produced in fertilized human and mouse oocytes code for DUX, a double homeodomain protein that promotes embryonic genome activation (EGA). Deleting Dux by genome editing at the 1- to 2-cell stage in the mouse impairs EGA an ...

2019

Automated Platform for Long-Term Culture and High-Content Phenotyping of Single C. elegans Worms

Martinus Adela Maria Gijs, Johan Auwerx, Matteo Cornaglia, Laurent Mouchiroud, Elena Katsyuba, Hüseyin Baris Atakan, Rongrong Xiang

The nematode Caenorhabditis elegans is a suitable model organism in drug screening. Traditionally worms are grown on agar plates, posing many challenges for long-term culture and phenotyping of animals under identical conditions. Microfluidics allows for ' ...

Nature Research2019

Dielectrophoresis‐assisted creation of cell aggregates under flow conditions using planar electrodes

Philippe Renaud, Harald Van Lintel, Jonathan Bastien Cottet, Soufian Lasli

We present a microfluidic platform allowing dielectrophoresis-assisted formation of cell aggregates of controlled size and composition under flow conditions. When specific ex- perimental conditions are met, negative dielectrophoresis allows efficient conce ...

2019

The H3K9 Methylation Writer SETDB1 and Its Reader MPP8 Cooperate to Silence Satellite DNA Repeats in Mouse Embryonic Stem Cells

Julien Paul André Pontis

SETDB1 (SET Domain Bifurcated histone lysine methyltransferase 1) is a key lysine methyltransferase (KMT) required in embryonic stem cells (ESCs), where it silences transposable elements and DNA repeats via histone H3 lysine 9 tri-methylation (H3K9me3), in ...

2019

The double-edged toxins : how Spiroplasma Ribosome-Inactivating Proteins affect Drosophila melanogaster life history traits

Mario Gonzalo Garcia Arraez

Many insect species are associated with endosymbiotic bacteria which have the particularity of living within host tissues. Endosymbionts benefit from this stable and nutritious environment, while providing ecological advantages to their host, such as prote ...

EPFL2018

Ovary-specific depletion of the nuclear receptor Nr5a2 compromises expansion of the cumulus oophorus but not fertilization by intracytoplasmic sperm injection

Kristina Schoonjans

The orphan nuclear receptor, liver receptor homolog-1 (aka Nuclear receptor subfamily 5, Group A, Member 2 (Nr5a2)), is widely expressed in mammalian tissues, and its ovarian expression is restricted to granulosa cells of activated follicles. We employed t ...

Society for the Study of Reproduction2017

New highly cytotoxic organic and organometallic bexarotene derivatives

Paul Joseph Dyson, Alexey Nazarov, Mathurin Baquié

A series of bifunctional ruthenium(II) arene compounds modified with bexarotene, a retinoid that selectively activates retinoid X receptors inducing cell differentiation and apoptosis and preventing drug resistance, are described. The bexarotene is tethere ...

Elsevier2017

DUX-family transcription factors regulate zygotic genome activation in placental mammals

Didier Trono, Evaristo Jose Planet Letschert, Julien Léonard Duc, Sonia Verp, Andrea Coluccio, Alberto De Iaco

In animal embryos, transcription is mostly silent for several cell divisions, until the release of the first major wave of embryonic transcripts through so-called zygotic genome activation (ZGA). Maternally provided ZGA-triggering factors have been identif ...

2017

Only Two Can Tango: Mast Cells Displace Epithelial Cells to Dance with ILC2s

Nicola Harris, Tiffany Babette Angélique Bouchery

Mast cells have been implicated in protective immunity to helminth infection, but the precise mechanism remains unclear. In this issue of Immunity, Shimokawa et al., 2017 report that mast cells are a bridge linking dying epithelial cells with effector type ...

Elsevier2017