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Concept

Neuroanatomy

Related publications (31)

Optimized photo-stimulation of halorhodopsin for long-term neuronal inhibition

Chuanqiang Zhang

Background Optogenetic silencing techniques have expanded the causal understanding of the functions of diverse neuronal cell types in both the healthy and diseased brain. A widely used inhibitory optogenetic actuator is eNpHR3.0, an improved version of the ...

2019

A system for planning and/or providing neurostimulation for a patient

Grégoire Courtine, Marco Capogrosso, Fabien Bertrand Paul Wagner, Vincent Delattre, Tomislav Milekovic, Flavio Raschella

The present invention relates to a system (10) for planning and/or providing neurostimulation for a patient, comprising: - a pathological spinal cord map storage module (48) for storing at least one pathological spinal cord map (49) describing the activati ...

2019

Influence of Minor Cr-Additions to the Growth of Columnar Dendrites in Al-Zn Alloys: Influence of Icosahedral Short Range Order in the Liquid

Michel Rappaz, Güven Kurtuldu

The effect of minute Cr additions on dendritic growth directions in Al-20 wt pct Zn alloy has been investigated. As first evidenced by Gonzales and Rappaz (Metall Mater Trans A 37:2797-2806, 2006) Al-Zn alloys exhibit a Dendrite Orientation Transition (DOT ...

SPRINGER2020

Dual-controlled optogenetic system for the rapid down-regulation of protein levels in mammalian cells

Patrick Andreas Gonschorek

Optogenetic switches are emerging molecular tools for studying cellular processes as they offer higher spatiotemporal and quantitative precision than classical, chemical-based switches. Light-controllable gene expression systems designed to upregulate prot ...

Nature Research2018

Selective Recruitment of Arm Motoneurons in Nonhuman Primates Using Epidural Electrical Stimulation of the Cervical Spinal Cord

Stéphanie Lacour, Grégoire Courtine, Marco Capogrosso, Jocelyne Bloch, Giuseppe Schiavone

Recovery of reaching and grasping ability is the priority for people with cervical spinal cord injury (SCI). Epidural electrical stimulation (EES) has shown promising results in improving motor control after SCI in various animal models and in humans. Nota ...

2018

Framework for the Development of Neuroprostheses: From Basic Understanding by Sciatic and Median Nerves Models to Bionic Legs and Hands

Stanisa Raspopovic, Giacomo Valle, Francesco Maria Petrini

Neuroprostheses based on electrical stimulation are becoming a therapeutic reality, dramatically improving the life of disabled people. They are based on neural interfaces that are designed to create an intimate contact with neural cells. These devices spe ...

Ieee-Inst Electrical Electronics Engineers Inc2017

The Human Central Pattern Generator for Locomotion: Does It Exist and Contribute to Walking?

Auke Ijspeert, Florin Dzeladini, Karen Minassian

The ability of dedicated spinal circuits, referred to as central pattern generators (CPGs), to produce the basic rhythm and neural activation patterns underlying locomotion can be demonstrated under specific experimental conditions in reduced animal prepar ...

Sage Publications Inc2017

In vivo cerebral metabolism of glioblastoma xenografts assessed with ¹H MRS, ¹³C MRS and ¹⁸F-FDG PET

Marta Lai

Magnetic resonance spectroscopy (MRS) is a powerful tool when studying metabolism in intact and living organs preserving cells in their natural microenvironment with minimal external interference. The unique insights offered by the observation of metabolic ...

EPFL2017

An organotypic slice culture to study the formation of calyx of Held synapses in-vitro

Ralf Schneggenburger, Elin Kristina Kronander

The calyx of Held, a large axo-somatic relay synapse containing hundreds of presynaptic active zones, is possibly the largest nerve terminal in the mammalian CNS. Studying its initial growth in-vitro might provide insights into the specification of synapti ...

2017

Neural probe combining microelectrodes and a droplet-based microdialysis collection system for high temporal resolution sampling

Philippe Renaud, Arnaud Bertsch, Guillaume Cédric Yves Petitpierre

We propose a novel neural probe which combines microfluidic channels with recording and stimulation electrodes. The developed microfabrication approach enables the concentration of every active element such as electrodes and the sampling inlet in close pro ...

Royal Society of Chemistry2016

Complete and long-term rescue of lesioned adult motoneurons by lentiviral-mediated expression of glial cell line-derived neurotrophic factor in the facial nucleus

Patrick Aebischer, Nicole Déglon

To date, delivery of neurotrophic factors has only allowed to transiently protect axotomized facial motoneurons against cell death. In the present report, long-term protection of these neurons was evaluated by continuously expressing the neurotrophic facto ...

2000