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Concept

Amphiphile

Related publications (29)

Discovery of macrocyclic inhibitors of challenging protein-protein interactions

Edward Jeffrey Will

Macrocycles are a therapeutic modality of interest for drugging challenging disease targets due to their high binding affinity and membrane permeability, enabling the discovery of orally delivered and efficacious therapeutics. Recent methods have enabled t ...

EPFL2024

Sulfated and sulfonated dendritic polyglycerols and use thereof as broad-spectrum virucidal agents

Francesco Stellacci, Matteo Gasbarri

The invention relates to dendritic polyglycerol (dPG) compounds with alkyl-sulfonate/ sulfate functional groups that irreversibly inhibit viral infection (virucidal effect) through multivalent interaction in nanomolar concentration range. While the compoun ...

2022

Computer Simulation of the Surface of Aqueous Ionic and Surfactant Solutions

Mária Lbadaoui-Darvas

The surface of aqueous solutions of simple salts was not the main focus of scientific attention for a long while. Considerable interest in studying such systems has only emerged in the past two decades, following the pioneering finding that large halide io ...

AMER CHEMICAL SOC2022

Post-translational regulation of neuronal differentiation

Jaipreet Singh Loomba

Glycosphingolipids (GSLs) are amphipathic lipid moieties that make up only 3% of the total lipid content of the cell and are almost exclusively expressed at the Plasma Membrane(PM). They are key drivers of signalling hotspots known as â lipid-raftsâ as ...

EPFL2021

Shear Stress-Responsive Polymersome Nanoreactors Inspired by the Marine Bioluminescence of Dinoflagellates

Esther Amstad, Antoine Claude Jean Vian

Some marine plankton called dinoflagellates emit light in response to the movement of surrounding water, resulting in a phenomenon called milky seas or sea sparkle. The underlying concept, a shear-stress induced permeabilisation of biocatalytic reaction co ...

Wiley-VCH Verlag GmbH2021

Carbon Nanomaterials from Oligoyne Surfactants

Enzo Jean Raymond Bomal

Carbonaceous nanocoatings such as diamond-like amorphous carbon or graphene layers exhibit remarkable properties in multiple fields, ranging from corrosion protection to electronics and lubrication. However, they are typically deposited from the vapor phas ...

EPFL2020

Self-Assembly of Microscopic Rods Due to Depletion Interaction

Ignacio Pagonabarraga Mora

In this article, using numerical simulations we investigate the self-assembly of rod-like particles in suspension due to depletion forces which naturally emerge due to the presence of smaller spherical depletant particles. We characterize the type of clust ...

2020

Reliable Langmuir Blodgett colloidal masks for large area nanostructure realization

Olivier Martin, Christian Santschi, Madasamy Thangamuthu

The fabrication of highly ordered nanostructures over large areas is key for many technologies and colloidal lithography using the Langmuir Blodgett technique appears a simple and straightforward way of reaching that goal. While this technique has been wid ...

2020

Fluorinated surfactants in droplet-based microfluidics: Influence of their composition on the properties of emulsion drops

Gianluca Nicolas Etienne

Miniaturization has been a driving force in many areas of science and technology, most notably in the electronics industry. Droplet-based microfluidics, a methode to produce emulsion drops in a controlled way and at high-throughputs, enables the miniaturiz ...

EPFL2019

Molecular Level Interfacial Studies of Nanoemulsions: Surface Structure, Specific Ion Effects and Stability

Evangelia Zdrali

This thesis is a study on the molecular structure of the interface of nanometer-sized oil droplets dispersed in water, a system known as oil-in-water nanoemulsion. The motivation for this research is the large significance of the interfacial nanostructures ...

EPFL2019

Micellization behavior of bile salt with pluronic (F-127) and synthesis of silver nanoparticles in a mixed system

Mohammad Khaja Nazeeruddin

The sequestrant is a substance used to cure bile salt diarrhea. They bind to bile salts by hydrophobic and electrostatic forces to stop them from contact with colon mucosa. The block copolymer could be used as bile salt binding agents. Herein, the physicoc ...

WILEY2019

Amphiphilic nanoparticle delivery enhances the anticancer efficacy of a TLR7 ligand via local immune activation

Francesco Stellacci, Ahmet Bekdemir

Although immunotherapy shows great promise for the long-term control of cancer, many tumors still fail to respond to treatment. To improve the outcome, the delivery of immunostimulants to the lymph nodes draining the tumor, where the antitumor immune respo ...

ELSEVIER SCI LTD2019

Selectively Permeable Double Emulsions

Esther Amstad, Irvine Lian Hao Ong

Natural organisms are made of different types of microcompartments, many of which are enclosed by cell membranes. For these organisms to display a proper function, the microcompartments must be selectively permeable. For example, cell membranes are typical ...

2019

Dissipative particle dynamics simulations of tri-block co-polymer and water: Phase diagram validation and microstructure identification

Ignacio Pagonabarraga Mora

In this study, the phase diagram of Pluronic L64 and water is simulated via dissipative particle dynamics (DPD). The peculiar structures that form when the concentration varies from dilute to dense (i.e., spherical and rod-like micelles, hexagonal and lame ...

2018

Nanoparticle Liposome Interactions

Zekiye Pelin Güven

Protein-mimetic materials are of great interest for biotechnology to grant protein-like properties to artificial systems. Additionally, these materials can be used to shed light on the fundamental properties of proteins in many environments. Nanoparticles, ...

EPFL2018

Formation of N-nitrosamines by micelle-catalysed nitrosation of aliphatic secondary amines

Urs von Gunten, Florian Frédéric Vincent Breider

N-Nitrosamines are an important class of potent human carcinogens and mutagens that can be present in water and wastewater. For instance, N-nitrosamines can be formed by reaction of nitrosating agents such as NO+ or N2O3 formed from nitrite under acidic co ...

2018

Biporous Metal-Organic Framework with Tunable CO2/CH4 Separation Performance Facilitated by Intrinsic Flexibility

Berend Smit, Kyriakos Stylianou, Seyedmohamad Moosavi, Daniele Ongari, Andrzej Gladysiak, Arunraj Chidambaram, Peter George Boyd, Kathryn Suzanne Deeg

In this work, we report the synthesis of SION-8, a novel metal-organic framework (MOF) based on Ca(II) and a tetracarboxylate ligand TBAPy(4-) endowed with two chemically distinct types of pores characterized by their hydrophobic and hydrophilic properties ...

2018

Biocompatible Amphiphilic Hydrogel–Solid Dimer Particles as Colloidal Surfactants

Esther Amstad

Emulsions of two immiscible liquids can slowly coalesce over time when stabilized by surfactant molecules. Pickering emulsions stabilized by colloidal particles can be much more stable. Here, we fabricate biocompatible amphiphilic dimer particles using a h ...

2017

Molecular-level characterization of curved water interfaces with sum frequency and second harmonic scattering

Nikolay Smolentsev

Aqueous interfaces are omnipresent in nature. Some of them are visible: droplets in clouds, aerosols, and surfaces of oceans, lakes, and rivers. Many more surfaces are hidden: water in contact with cell membranes, proteins, and the surface of droplets in e ...

EPFL2017

Influence of Block versus Random Monomer Distribution on the Cellular Uptake of Hydrophilic Copolymers

Harm-Anton Klok, John Moraes, Raoul Peltier

The use of polymers has revolutionized the field of drug delivery in the past two decades. Properties such as polymer size, charge, hydrophilicity, or branching have all been shown to play an important role in the cellular internalization of polymeric syst ...

2016