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Explores p53's pivotal role in cellular stability, DNA repair, and tumor suppression, emphasizing TP53 mutations and DNA double-strand break repair mechanisms.
Delves into the molecular basis of genetic diseases, discussing specific examples like Phenylketonuria and Haemophilia A, and the development of small molecule drugs for genetic disorders.
Covers the decline of cancer death rates, conventional and targeted anticancer drugs, surgical oncology, radiotherapy, chemotherapy, resistance mechanisms, and the history of targeted drugs and EGFR targeting.
Explores DNA repair mechanisms, including BER, MMR, NER, and repair of double-strand breaks, as well as the impact of UV-induced lesions and resistance to PARP inhibitors.
Covers DNA damage types, repair mechanisms, UV-induced damage, survival curves, NER deficiency consequences, tumor suppressor genes, and cancer prevention.
