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Concept

Spliceosome

Related publications (5)

Short-lived AUF1 p42-binding mRNAs of RANKL and BCL6 have two distinct instability elements each

Philipp Bucher, Giovanna Ambrosini, Lukas Kühn, Ramona Pauchard-Batschulat, Barbara Grisoni-Neupert

Regulation of mRNA stability by RNA-protein interactions contributes significantly to quantitative aspects of gene expression. We have identified potential mRNA targets of the AU-rich element binding protein AUF1. Myc-tagged AUF1 p42 was induced in mouse N ...

2018

Implication of the box C/D snoRNP assembly factor Rsa1p in U3 snoRNP assembly

Benjamin Marcel Daniel Rothé

The U3 box C/D snoRNA is one key element of 90S pre-ribosome. It contains a 5' domain pairing with pre-rRNA and the U3(B/C) and U3(C'/D) motifs for U3 packaging into a unique small nucleolar ribonucleoprotein particle (snoRNP). The RNA-binding protein Snu1 ...

Oxford University Press (OUP)2017

Who Activates the Nucleophile in Ribozyme Catalysis? An Answer from the Splicing Mechanism of Group II Introns

Ursula Röthlisberger, Giulia Palermo

Group II introns are Mg2+-dependent ribozymes that are considered to be the evolutionary ancestors of the eukaryotic spliceosome, thus representing an ideal model system to understand the mechanism of conversion of premature messenger RNA (mRNA) into matur ...

2016

Protein Domain Prediction and Alternative Splicing Histories : a Modular View

Yann Christinat

Modularity is at the core of bioinformatics. Here we focused on two different building blocks: protein domains and exons. While protein domains enable us to study the protein‚s functions, exons allow us to understand the evolution of the former. However, a ...

EPFL2012

Highly Specific Methods for the Prediction of Genes Regulated by MicroRNAs

Ray Marcel Marin Florez

MicroRNAs (miRNAs) comprise a large set of short noncoding RNAs that bind to messenger RNAs (mRNAs) to reduce their translation into functional proteins. Computational prediction of miRNA targets is the first stage in the discovery and validation of new re ...

EPFL2012