Publication

Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments

2026

Abstract

Recent progress in glycan research has been driven by widespread implementations of metabolic oligosaccharide engineering. Complementing existing approaches, we here introduce bifunctional, UV‐crosslinkable, and clickable N‐acetylglucosamine and N‐acetylgalactosamine analogues, which enable direct visualization of the intracellular probe distribution as well as distinguishing monomeric and macromolecule‐bound fractions. Using this feature, we find that monomeric N‐acetylmonosaccharides partition into RNA‐rich nuclear compartments such as nuclear speckles and nucleoli. This suggests the existence of spatially separated N‐acetylmonosaccharide pools within the nucleoplasm. Taken together, bifunctional N‐acetylmonosaccharide probes are versatile discovery tools for probing intracellular localization of monosaccharides.

Official source

https://infoscience.epfl.ch/entities/publication/1f002d27-c633-4b9f-b1c5-3696df36013a

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2026

Abstract

Official source

https://infoscience.epfl.ch/entities/publication/1f002d27-c633-4b9f-b1c5-3696df36013a

About this result

Related concepts (31)

Cell nucleus

The cell nucleus (; : nuclei) is a membrane-bound organelle found in eukaryotic cells. Eukaryotic cells usually have a single nucleus, but a few cell types, such as mammalian red blood cells, have no nuclei, and a few others including osteoclasts have many. The main structures making up the nucleus are the nuclear envelope, a double membrane that encloses the entire organelle and isolates its contents from the cellular cytoplasm; and the nuclear matrix, a network within the nucleus that adds mechanical support.

Monosaccharide

Monosaccharides (from Greek monos: single, sacchar: sugar), also called simple sugars, are the simplest forms of sugar and the most basic units (monomers) from which all carbohydrates are built. They are usually colorless, water-soluble, and crystalline solids. Contrary to their name (sugars), only some monosaccharides have a sweet taste. Most monosaccharides have the formula (CH2O) (though not all molecules with this formula are monosaccharides). Examples of monosaccharides include glucose (dextrose), fructose (levulose), and galactose.

Disaccharide

A disaccharide (also called a double sugar or biose) is the sugar formed when two monosaccharides are joined by glycosidic linkage. Like monosaccharides, disaccharides are simple sugars soluble in water. Three common examples are sucrose, lactose, and maltose. Disaccharides are one of the four chemical groupings of carbohydrates (monosaccharides, disaccharides, oligosaccharides, and polysaccharides). The most common types of disaccharides—sucrose, lactose, and maltose—have 12 carbon atoms, with the general formula C12H22O11.

Related publications (1)

Bifunctional Monosaccharides Preferentially Localize to Nuclear Subcompartments

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