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Concept

Gnathostomata

Related publications (13)

Development of a Robotic Microsurgeon for Embryonic Research

Ece Özelçi

Understanding how biological matter takes its shape is instrumental to biology, bioengineering, medicine, and bioinspired engineering. Gaining information on the principles of morphogenesis could enable clinicians to correct developmental abnormalities, ev ...

EPFL2023

A Robotic Surgery Platform for Automated Tissue Micromanipulation in Zebrafish Embryos

Mahmut Selman Sakar, Andrew Charles Oates, Ece Özelçi, Laurel Ann Rohde

Microsurgical manipulations are key experimental techniques in life science research, particularly in embryology. These techniques are most often performed manually by highly skilled scientists, posing limitations on speed, precision, and reproducibility. ...

2024

Mutations in Bcl9 and Pygo genes cause congenital heart defects by tissue-specific perturbation of Wnt/beta-catenin signaling

Michel Aguet

Bcl9 and Pygopus (Pygo) are obligate Wnt/beta-catenin cofactors in Drosophila, yet their contribution to Wnt signaling during vertebrate development remains unresolved. Combining zebrafish and mouse genetics, we document a conserved, beta-catenin-associate ...

COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2018

Topological Domains, Metagenes, and the Emergence of Pleiotropic Regulations at Hox Loci

Denis Duboule, Fabrice Daniel Darbellay

Hox gene clusters of jaw vertebrates display a tight genomic organization, which has no equivalent in any other bilateria genomes sequenced thus far. It was previously argued that such a topological consolidation toward a condensed, metagenic structure was ...

Elsevier Academic Press Inc2016

Persistence, period and precision of autonomous cellular oscillators from the zebrafish segmentation clock

Andrew Charles Oates

In vertebrate development, the sequential and rhythmic segmentation of the body axis is regulated by a "segmentation clock". This clock is comprised of a population of coordinated oscillating cells that together produce rhythmic gene expression patterns in ...

2016

Sequential pattern formation governed by signaling gradients

Andrew Charles Oates

Rhythmic and sequential segmentation of the embryonic body plan is a vital developmental patterning process in all vertebrate species. However, a theoretical framework capturing the emergence of dynamic patterns of gene expression from the interplay of cel ...

2016

Intra- and interspecific social challenges modulate the levels of an androgen precursor in a seasonally territorial tropical damselfish

Studies on different vertebrate groups have provided evidence that androgen levels in males increase after competitive social interactions during the breeding season, as postulated by the Challenge Hypothesis. However, social modulation of androgen levels ...

Academic Press Inc Elsevier Science2015

A switch between topological domains underlies HoxD genes collinearity in mouse limbs

Didier Trono, Denis Duboule, Marion Leleu, Guillaume Andrey

Hox genes are major determinants of the animal body plan, where they organize structures along both the trunk and appendicular axes. During mouse limb development, Hoxd genes are transcribed in two waves: early on, when the arm and forearm are specified, a ...

American Association for the Advancement of Science2013

Role of a polymorphism in a Hox/Pax-responsive enhancer in the evolution of the vertebrate spine

Denis Duboule

Patterning of the vertebrate skeleton requires the coordinated activity of Hox genes. In particular, Hox10 proteins are essential to set the transition from thoracic to lumbar vertebrae because of their rib-repressing activity. In snakes, however, the thor ...

National Academy of Sciences2013

Gut-associated microbes of Drosophila melanogaster

Bruno Lemaitre

There is growing interest in using Drosophila melanogaster to elucidate mechanisms that underlie the complex relationships between a host and its microbiota. In addition to the many genetic resources and tools Drosophila provides, its associated microbiota ...

2012

Epigenetic temporal control of mouse Hox genes in vivo

Denis Duboule

During vertebrate development, the temporal control of Hox gene transcriptional activation follows the genomic order of the genes within the Hox clusters. Although it is recognized that this "Hox clock" serves to coordinate body patterning, the underlying ...

American Association for the Advancement of Science2009

Rostral and caudal pharyngeal arches share a common neural crest ground pattern

Denis Duboule

In vertebrates, face and throat structures, such as jaw, hyoid and thyroid cartilages develop from a rostrocaudal metameric series of pharyngeal arches, colonized by cranial neural crest cells (NCCs). Colinear Hox gene expression patterns underlie arch spe ...

2009

Notch controls embryonic Schwann cell differentiation, postnatal myelination and adult plasticity

Freddy Radtke

Notch signaling is central to vertebrate development, and analysis of Notch has provided important insights into pathogenetic mechanisms in the CNS and many other tissues. However, surprisingly little is known about the role of Notch in the development and ...

2009