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Related publications (22)

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Multiscale Porosity Microfluidics to Study Bacterial Transport in Heterogeneous Chemical Landscapes

Francesco Carrara, Jiande Zhou

Microfluidic models are proving to be powerful systems to study fundamental processes in porous media, due to their ability to replicate topologically complex environments while allowing detailed, quantitative observations at the pore scale. Yet, while por ...

Wiley2024

Two antagonistic response regulators control Pseudomonas aeruginosa polarization during mechanotaxis

Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Zaïnebe Dhirani, Marco Julian Kühn

The opportunistic pathogen Pseudomonas aeruginosa adapts to solid surfaces to enhance virulence and infect its host. Type IV pili (T4P), long and thin filaments that power surface-specific twitching motility, allow single cells to sense surfaces and contro ...

WILEY2023

Material Substrate Physical Properties Control Pseudomonas aeruginosa Biofilm Architecture

Alexandre Louis André Persat, Alice Cont

The biofilm lifestyle is the most widespread survival strategy in the bacterial world. Pseudomonas aeruginosa biofilms cause chronic infections and are highly recalcitrant to antimicrobials. The genetic requirements allowing P. aeruginosa to grow into biof ...

AMER SOC MICROBIOLOGY2023

Characterization of Pseudomonas aeruginosa mechanosensing through label-free imaging of type IV pili

Lorenzo Anton-Louis Talà

Bacteria are ubiquitously found in all sorts of environment. They're found in the ocean, soil, or even in our guts or on our skin. Independently of their niche, they can transition from a planktonic state were they freely swim in an aqueous environment to ...

EPFL2022

Hydrodynamic and geometric effects in the sedimentation of model run-and-tumble microswimmers

Ignacio Pagonabarraga Mora

The sedimentation process in an active suspension is the result of the competition between gravity and the autonomous motion of particles. We carry out simulations of run-and-tumble squirmers that move in a fluid medium, focusing on the dependence of the n ...

ROYAL SOC CHEMISTRY2022

Microfluidic Platforms for the Study of Bacterial Metabolism and Antimicrobial Susceptibility Testing

Yang Liu

Fast spreading antimicrobial resistance (AMR) is an emerging major public health issue. New therapeutic and diagnostic paradigms must be implemented to counteract this evolution. In this respect, fast antimicrobial susceptibility testing (AST) plays an imp ...

EPFL2021

Mechanotaxis directs Pseudomonas aeruginosa twitching motility

Alexandre Louis André Persat, Lorenzo Anton-Louis Talà, Xavier Jean-Yves Pierrat, Jose Negrete Jr, Zaïnebe Dhirani, Marco Julian Kühn

The opportunistic pathogen Pseudomonas aeruginosa explores surfaces using twitching motility powered by retractile extracellu-lar filaments called type IV pili (T4P). Single cells twitch by sequen-tial T4P extension, attachment, and retraction. How single ...

National Academy of Sciences2021

The molecular treasure box of environmental Vibrio cholerae strains

Natalia Carolina Drebes Dorr

Cholera pandemics have been affecting humankind for centuries and are still considered a major public health problem, especially in regions around the world with poor access to clean water and sanitation. Cholera pandemics are caused by a specific lineage ...

EPFL2021

Loopy Levy flights enhance tracer diffusion in active suspensions

Tomohiko Sano

A theoretical framework describing the hydrodynamic interactions between a passive particle and an active medium in out-of-equilibrium systems predicts long-range Levy flights for the diffusing particle driven by the density of the active component. Browni ...

2020

Pseudomonas aeruginosa orchestrates twitching motility by sequential control of type IV pili movements

Alexandre Louis André Persat, Lorenzo Anton-Louis Talà

Prokaryotes have the ability to walk on surfaces using type IV pili (TFP), a motility mechanism known as twitching(1,2). Molecular motors drive TFP extension and retraction, but whether and how these movements are coordinated is unknown(3). Here, we reveal ...

NATURE PUBLISHING GROUP2019

Direct measurement of Lighthill's energetic efficiency of a minimal magnetic microswimmer

Ignacio Pagonabarraga Mora

The realization of artificial microscopic swimmers able to propel in viscous fluids is an emergent research field of fundamental interest and vast technological applications. For certain functionalities, the efficiency of the microswimmer in converting the ...

2019

The type IV pilus protein PilU functions as a PilT-dependent retraction ATPase

Melanie Blokesch, Sandrine Stutzmann, Candice Stoudmann, David William Adams, Jorge André Matias Pereira

Type IV pili are dynamic cell surface appendages found throughout the bacteria. The ability of these structures to undergo repetitive cycles of extension and retraction underpins their crucial roles in adhesion, motility and natural competence for transfor ...

2019

The Hydrodynamics of a Micro-Rocket Propelled by a Deformable Bubble

François Gallaire, Lailai Zhu, Giacomo Gallino

We perform simulations to study the hydrodynamics of a conical-shaped swimming micro-robot that ejects catalytically produced bubbles from its inside. We underline the nontrivial dependency of the swimming velocity on the bubble deformability and on the ge ...

2019

When droplets deform, break up and propel microswimmers

Giacomo Gallino

This thesis investigates the motion and breakup of droplets in low-Reynolds-number flows, focusing on two aspects. In the first part, we study the breakup of droplets in subcritical flow conditions, when there exists a linearly stable solution for the drop ...

EPFL2018

Soft micromachines with programmable motility and morphology

Mahmut Selman Sakar

Nature provides a wide range of inspiration for building mobile micromachines that can navigate through confined heterogenous environments and perform minimally invasive environmental and biomedical operations. For example, microstructures fabricated in th ...

Nature Research2016

Structured light enables biomimetic swimming and versatile locomotion of photoresponsive soft microrobots

Tian Qiu

Microorganisms move in challenging environments by periodic changes in body shape. In contrast, current artificial microrobots cannot actively deform, exhibiting at best passive bending under external fields. Here, by taking advantage of the wireless, scal ...

Nature Publishing Group2016

Microfluidic co-culture platform to quantify chemotaxis of primary stem cells

Jörg Hülsken, Zuzana Tatárová

Functional analysis of primary tissue-specific stem cells is hampered by their rarity. Here we describe a greatly miniaturized microfluidic device for the multiplexed, quantitative analysis of the chemotactic properties of primary, bone marrow-derived mese ...

Royal Soc Chemistry2016

Three-dimensional chemotaxis-driven aggregation of tumor cells

Alessandro De Simone

One of the most important steps in tumor progression involves the transformation from a differentiated epithelial phenotype to an aggressive, highly motile phenotype, where tumor cells invade neighboring tissues. Invasion can occur either by isolated mesen ...

Nature Publishing Group2015

Swimming by reciprocal motion at low Reynolds number

Tian Qiu

Biological microorganisms swim with flagella and cilia that execute nonreciprocal motions for low Reynolds number (Re) propulsion in viscous fluids. This symmetry requirement is a consequence of Purcell's scallop theorem, which complicates the actuation sc ...

Nature Publishing Group2014

A wearable system for monitoring the velocity variability in open water swimming and triathlon

Kamiar Aminian, Farzin Dadashi, Grégoire Millet

Pacing tactics in the swimming bout notably influences the overall triathlon performance. Besides, the swimming velocity affects the energy expenditure (EE). Based on our previous works to estimate the swimming velocity, here we propose a system to measure ...

2013