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Concept

Constipation

Related publications (5)

Dietary Fiber Is Essential to Maintain Intestinal Size, L-Cell Secretion, and Intestinal Integrity in Mice

Kristina Schoonjans

Dietary fiber has been linked to improved gut health, yet the mechanisms behind this association remain poorly understood. One proposed mechanism is through its influence on the secretion of gut hormones, including glucagon-like peptide-1 (GLP-1) and gluca ...

FRONTIERS MEDIA SA2021

Natural compounds boldine and menthol are antagonists of human 5-HT

Rudolf Hovius

Background Impaired 5-HT3 receptor function is likely involved in the pathogenesis of functional gastrointestinal disorders (FGID) and 5-HT3 receptor antagonists are effective treatments for chemotherapy-induced nausea and vomiting (CINV) and irritable bow ...

2014

The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice

Kristina Schoonjans

BACKGROUND & AIMS: Abnormal delivery of bile acids (BAs) to the colon as a result of disease or therapy causes constipation or diarrhea by unknown mechanisms. The G protein-coupled BA receptor TGR5 (or GPBAR1) is expressed by enteric neurons and endocrine ...

W B Saunders Co-Elsevier Inc2013

Serotonin receptor diversity in the human colon: Expression of serotonin type 3 receptor subunits 5-HT3C, 5-HT3D, and 5-HT3E

Rudolf Hovius

Since the first description of 5-HT3 receptors more than 50 years ago, there has been speculation about the molecular basis of their receptor heterogeneity. We have cloned the genes encoding novel 5-HT3 subunits 5-HT3C, 5-HT3D, and 5-HT3E and have shown th ...

Wiley-Blackwell2010

Electrical and mechanical activity of the intestine : experimental assessment and biophysical modeling

Mattia Bertschi

The intestine is today still an organ whose mechanisms of functions are not fully understood. The diffculty in its understanding comes from the fact that it is regulated by a complex network of signals of different natures. Granting that a multitude of exp ...

EPFL2005