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Concept

New Drug Application

Related lectures (25)

Immunoediting of Tumors: Experimental Evidence and Mechanisms

Explores tumor immunoediting, mechanisms of tumor escape, and cancer immunotherapy, emphasizing immune response regulation and recent drug approvals.

Pharmacogenetics: Drug Response and Genetic Variability

Delves into pharmacogenetics, exploring genetic influences on drug response variability and metabolism.

Pharmacological Targets and Interventions

Explores targets for drug action and the design of specific inhibitors.

Introduction to Tissue Engineering

Covers the basics of tissue engineering, laboratory introductions, recommended courses, autografting, allografting, FDA-approved tissue products, and current research challenges.

Drug Development and Regulations: Europe

Explores drug development and regulations in Europe, focusing on clinical trials, regulatory frameworks, and marketing authorization procedures.

Pharmacodynamics and Drug Targets

Explores pharmacodynamics, drug targets, the renin-angiotensin system, ACE inhibitors, diuretics, and exam questions.

Personalized Medicine: Genetic Make-up Elucidation

Explores the significance of genetic make-up elucidation for personalized medicine, focusing on DNA-based risk assessment and tailored treatments.

Activity-based Protein Profiling: Druggable Sites Identification

Explores Activity-based Protein Profiling for druggable site identification and strategies to minimize off-target reactivity of covalent inhibitors.

Protein-Ligand Interactions: Importance and Affinity

Explores the importance of protein-ligand interactions, focusing on binding affinities and energetic landscapes, with implications for drug development and specificity.

Interrogating Drugs' Mode of Action

Delves into enzyme inhibition, reversible and irreversible binding, and covalent drugs, exploring drug modes of action and their impact on drug efficacy.

Genomic Medicine: From Research to Clinic

Explores the transition of genomic medicine from research to clinic, emphasizing personalized medicine and ethical considerations.

PROTACs: Catalytic Protein Knockdown Strategy

Explores PROTACs, a catalytic protein knockdown strategy with potential in tumor treatment and drug development.

Precision Electrophile Signaling: Tools for Unconventional Codes

Presents T-REX, a method for studying electrophile signaling in vivo and its applications in live cells and animal models.

Platinum Drugs: Chemistry and Cancer Treatment

Covers the role of platinum-based drugs in cancer treatment and their chemical mechanisms.

Interrogating SAR in Medical Chemistry Log in to Mediaspace to watch this video

Delves into the fundamentals of medicinal chemistry, emphasizing the interrogation of Structure-Activity Relationships (SAR) in drug design.

Identifying Correct Target in Medical Chemistry Log in to Mediaspace to watch this video

Explores target identification, efficacy, and safety in medical chemistry, emphasizing the importance of on-target specificity and drug design.

Preclinical Animal Models: Selection & Rationale Log in to Mediaspace to watch this video

Explores the selection and rationale of preclinical animal models in drug development, emphasizing the 10 to 15-year path to a marketed small-molecule drug.

Causality and Clinical Studies Log in to Mediaspace to watch this video

Explores causality, clinical studies, new drug evaluation, confounding factors, and data analysis methods.

Chemical Biology Fundamentals: Covalent Drug Efficacy Log in to Mediaspace to watch this video

Delves into the efficacy of covalent drugs in chemical biology, exploring reversible vs. irreversible binders and mechanism-based inactivators.

Fragment-Based Drug Discovery: Concepts & Technologies Log in to Mediaspace to watch this video

Covers the concepts and technologies of fragment-based drug discovery, exploring hit identification, lead optimization, and screening methods.