Lecture

Real-world Evidence in Health Data Sciences

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In course

MATH-448: Statistical analysis of network data

A first course in statistical network analysis and applications. ...

Description

This lecture discusses the importance of real-world evidence in health data sciences, focusing on observational research, reliability, and reproducibility. The instructor presents examples of major bleeding risk comparisons among atrial fibrillation patients and the use of negative controls in drug safety studies. The lecture emphasizes the need for systematic, open-source approaches in large-scale analytics to improve the quality and reliability of health data analysis.

Instructor

Sofia Charlotta Olhede

I am a professor of Statistics at EPFL. I did my PhD in Mathematics at Imperial College London, and graduated in 2003. I was an assistant professor (lecturer) at Imperial College London 2002-2006, and an associate professor (senior lecturer) 2006-2007. In 2007 I moved to University College London and became a full professor. I moved to EPFL in 2019, and in 2018 I became an Institute of Mathematical Statistics Fellow with citation “For seminal contributions to the theory and application of large and heteroge

Official source

Ontological neighbourhood

Health sciences

Cardiology: Cardiovascular disease

Related concepts (31)

Atrial flutter

Atrial flutter (AFL) is a common abnormal heart rhythm that starts in the atrial chambers of the heart. When it first occurs, it is usually associated with a fast heart rate and is classified as a type of supraventricular tachycardia. Atrial flutter is characterized by a sudden-onset (usually) regular abnormal heart rhythm on an electrocardiogram (ECG) in which the heart rate is fast. Symptoms may include a feeling of the heart beating too fast, too hard, or skipping beats, chest discomfort, difficulty breathing, a feeling as if one's stomach has dropped, a feeling of being light-headed, or loss of consciousness.

Ventricular fibrillation

Ventricular fibrillation (V-fib or VF) is an abnormal heart rhythm in which the ventricles of the heart quiver. It is due to disorganized electrical activity. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. This is followed by sudden cardiac death in the absence of treatment. Ventricular fibrillation is initially found in about 10% of people with cardiac arrest. Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, long QT syndrome, electric shock, or intracranial hemorrhage.

Premature atrial contraction

Premature atrial contraction (PAC), also known as atrial premature complexes (APC) or atrial premature beats (APB), are a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria. While the sinoatrial node typically regulates the heartbeat during normal sinus rhythm, PACs occur when another region of the atria depolarizes before the sinoatrial node and thus triggers a premature heartbeat, in contrast to escape beats, in which the normal sinoatrial node fails, leaving a non-nodal pacemaker to initiate a late beat.

Catheter ablation

Catheter ablation is a procedure that uses radio-frequency energy or other sources to terminate or modify a faulty electrical pathway from sections of the heart of those who are prone to developing cardiac arrhythmias such as atrial fibrillation, atrial flutter and Wolff-Parkinson-White syndrome. If not controlled, such arrhythmias increase the risk of ventricular fibrillation and sudden cardiac arrest. The ablation procedure can be classified by energy source: radiofrequency ablation and cryoablation.

Open source

Open source is source code that is made freely available for possible modification and redistribution. Products include permission to use the source code, design documents, or content of the product. The open-source model is a decentralized software development model that encourages open collaboration. A main principle of open-source software development is peer production, with products such as source code, blueprints, and documentation freely available to the public.

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