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Lecture

Real-world Evidence in Health Data Sciences

In course

MATH-448: Statistical analysis of network data

A first course in statistical network analysis and applications. ...

Description

This lecture discusses the importance of real-world evidence in health data sciences, focusing on observational research, reliability, and reproducibility. The instructor presents examples of major bleeding risk comparisons among atrial fibrillation patients and the use of negative controls in drug safety studies. The lecture emphasizes the need for systematic, open-source approaches in large-scale analytics to improve the quality and reliability of health data analysis.

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Instructor

Sofia Charlotta Olhede

Sofia Olhede is a professor of Statistics at EPFL in Switzerland. She joined UCL prior to this in 2007, before which she was a senior lecturer of statistics (associate professor) at Imperial College London (2006-2007), a lecturer of statistics (assistant professor) (2002-2006), where she also completed her PhD in 2003 and MSci in 2000. She has held three research fellowships while at UCL: UK Engineering and Physical Sciences Springboard fellowship as well as a five-year Leadership fellowship, and now holds a European Research Council Consolidator fellowship. Sofia has contributed to the study of stochastic processes; time series, random fields and networks. Sofia was part of the multi-institutional team that set up the UK national data science institute, the Alan Turing Institute. She organised and served as chair of the science committee that developed the initial 500 000 pounds scientific programme of the institute; peer-reviewing over 100 workshop proposals and hosting over 30. She also chaired the first recruitment wave of the institute hiring 13 data scientists as a multi-university recruitment drive. Sofia was a member of the Royal Society and British Academy Data Governance Working Group, and the Royal Society working group on machine learning. Most recently she was one of 3 commissioners on a law society commission on the usage of algorithms in the justice system.

Official source

Ontological neighbourhood

Health sciences

Cardiology: Cardiovascular disease

Related concepts (32)

Atrial fibrillation

Atrial fibrillation (AF or A-fib) is an abnormal heart rhythm (arrhythmia) characterized by rapid and irregular beating of the atrial chambers of the heart. It often begins as short periods of abnormal beating, which become longer or continuous over time. It may also start as other forms of arrhythmia such as atrial flutter that then transform into AF. Episodes can be asymptomatic. Symptomatic episodes may involve heart palpitations, fainting, lightheadedness, shortness of breath, or chest pain.

Ventricular fibrillation

Ventricular fibrillation (V-fib or VF) is an abnormal heart rhythm in which the ventricles of the heart quiver. It is due to disorganized electrical activity. Ventricular fibrillation results in cardiac arrest with loss of consciousness and no pulse. This is followed by sudden cardiac death in the absence of treatment. Ventricular fibrillation is initially found in about 10% of people with cardiac arrest. Ventricular fibrillation can occur due to coronary heart disease, valvular heart disease, cardiomyopathy, Brugada syndrome, long QT syndrome, electric shock, or intracranial hemorrhage.

Atrial flutter

Atrial flutter (AFL) is a common abnormal heart rhythm that starts in the atrial chambers of the heart. When it first occurs, it is usually associated with a fast heart rate and is classified as a type of supraventricular tachycardia. Atrial flutter is characterized by a sudden-onset (usually) regular abnormal heart rhythm on an electrocardiogram (ECG) in which the heart rate is fast. Symptoms may include a feeling of the heart beating too fast, too hard, or skipping beats, chest discomfort, difficulty breathing, a feeling as if one's stomach has dropped, a feeling of being light-headed, or loss of consciousness.

Premature atrial contraction

Premature atrial contraction (PAC), also known as atrial premature complexes (APC) or atrial premature beats (APB), are a common cardiac dysrhythmia characterized by premature heartbeats originating in the atria. While the sinoatrial node typically regulates the heartbeat during normal sinus rhythm, PACs occur when another region of the atria depolarizes before the sinoatrial node and thus triggers a premature heartbeat, in contrast to escape beats, in which the normal sinoatrial node fails, leaving a non-nodal pacemaker to initiate a late beat.

Catheter ablation

Catheter ablation is a procedure that uses radio-frequency energy or other sources to terminate or modify a faulty electrical pathway from sections of the heart of those who are prone to developing cardiac arrhythmias such as atrial fibrillation, atrial flutter and Wolff-Parkinson-White syndrome. If not controlled, such arrhythmias increase the risk of ventricular fibrillation and sudden cardiac arrest. The ablation procedure can be classified by energy source: radiofrequency ablation and cryoablation.

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