Evolution of mammalian auditory ossicles

Species-specific regulation of XIST by the JPX/FTX orthologs

X chromosome inactivation (XCI) is an essential process, yet it initiates with remarkable diversity in various mammalian species. XIST, the main trigger of XCI, is controlled in the mouse by an interplay of lncRNA genes (LRGs), some of which evolved concom ...

OXFORD UNIV PRESS2023

An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates

Matthias Lütolf, Sebastian Maerkl, Zoe Newell Swank, Stefano Davide Vianello, Julia Tischler, Hao-An Hsiung

We present a low-cost, do-it-yourself system for complexmammalian cell culture under dynamically changing medium formulations by integrating conventional multi-well tissue culture plates with simple microfluidic control and system automation. We demonstrat ...

2022

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

Matthias Lütolf, Stefano Davide Vianello

Research in developmental biology has been recently enriched by a multitude of in vitro models recapitulating key milestones of mammalian embryogenesis. These models obviate the challenge posed by the inaccessibility of implanted embryos, multiply experime ...

Cell Press - Elsevier2019

Hotair Is Dispensible for Mouse Development

Denis Duboule, Anamaria Necsulea

Despite the crucial importance of Hox genes functions during animal development, the mechanisms that control their transcription in time and space are not yet fully understood. In this context, it was proposed that Hotair, a lncRNA transcribed from within ...

Public Library Science2016

A mammalian transcription factor-specific peptide repository for targeted proteomics

Bart Deplancke, Marc Moniatte, Romain Hamelin, Jovan Simicevic

Site-specific transcription factors (TFs) play an essential role in mammalian development and function as they are vital for the majority of cellular processes. Despite their biological importance, TF proteomic data is scarce in the literature, likely due ...

Wiley-VCH GmbH2015

Evolutionary dynamics of coding and non-coding transcriptomes

Anamaria Necsulea

Gene expression changes may underlie much of phenotypic evolution. The development of high-throughput RNA sequencing protocols has opened the door to unprecedented large-scale and cross-species transcriptome comparisons by allowing accurate and sensitive a ...

Nature Publishing Group2014

RoboGen: Robot Generation through Artificial Evolution

Dario Floreano, Joshua Evan Auerbach, Przemyslaw Mariusz Kornatowski, Andrea Maesani, Grégoire Hilaire Marie Heitz, Ludovic Daler, Deniz Aydin, Ilya Loshchilov, Pradeep Ruben Fernando, Deniz Aydin

Science instructors from a wide range of disciplines agree that hands-on laboratory components of courses are pedagogically necessary (Freedman, 1997). However, certain shortcomings of current laboratory exercises have been pointed out by several authors ( ...

The MIT Press2014

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

Anne Grapin-Botton

BACKGROUND: Endoderm organ primordia become specified between gastrulation and gut tube folding in Amniotes. Although the requirement for RA signaling for the development of a few individual endoderm organs has been established a systematic assessment of i ...

Public Library of Science2009

Evolution of mammalian auditory ossicles

Species-specific regulation of XIST by the JPX/FTX orthologs

Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations

An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

Hotair Is Dispensible for Mouse Development

A mammalian transcription factor-specific peptide repository for targeted proteomics

Evolutionary dynamics of coding and non-coding transcriptomes

RoboGen: Robot Generation through Artificial Evolution

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis

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Species-specific regulation of XIST by the JPX/FTX orthologs

Wide-scale identification of novel/eliminated genes responsible for evolutionary transformations

An automated do-it-yourself system for dynamic stem cell and organoid culture in standard multi-well plates

Understanding the Mechanobiology of Early Mammalian Development through Bioengineered Models

Hotair Is Dispensible for Mouse Development

A mammalian transcription factor-specific peptide repository for targeted proteomics

Evolutionary dynamics of coding and non-coding transcriptomes

RoboGen: Robot Generation through Artificial Evolution

Retinoic acid signaling organizes endodermal organ specification along the entire antero-posterior axis