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Anesthesiology

Related publications (28)

A Needle-Shaped Electrochemical Sensor in Platinum for Robust Monitoring of Anaesthetics

Sandro Carrara

A needle-shaped electrochemical sensor based on platinum electrodes is proposed in this paper. These platinum electrodes provide improved mechanical properties with respect to previous prototypes proposed in literature. This makes them suitable for inserti ...

IEEE2022

Smart Portable Pen for Continuous Monitoring of Anaesthetics in Human Serum With Machine Learning

Sandro Carrara, Danilo Demarchi, Simone Aiassa, Mandresy Ivan Ny Hanitra

Continuous monitoring of anaesthetics infusion is demanded by anaesthesiologists to help in defining personalized dose, hence reducing risks and side effects. We propose the first piece of technology tailored explicitly to close the loop between anaesthesi ...

2021

Measuring Glycolytic Activity with Hyperpolarized [2H7, U-13C6] D-Glucose in the Naive Mouse Brain under Different Anesthetic Conditions

Rolf Gruetter, Bernard Lanz, Mor-Miri Mishkovsky, Andrea Capozzi, Yves Pilloud, Emmanuelle Ines Flatt

Glucose is the primary fuel for the brain; its metabolism is linked with cerebral function. Different magnetic resonance spectroscopy (MRS) techniques are available to assess glucose metabolism, providing complementary information. Our first aim was to inv ...

2021

Pencil Graphite Needle-Shaped Biosensor for Anaesthetic Monitoring in Human Serum

Sandro Carrara, Danilo Demarchi, Simone Aiassa

Direct and online continuous monitoring of anaesthetic intake by the patient's blood stream improves practices in the critical procedure of anaesthesia. Several systems have been proposed to address this challenge. Electrochemical techniques are highly app ...

IEEE2020

Transient Electronics for Smart Biodegradable Medical Implants

Matthieu Jean Michel Rüegg

Bioresorbable implantable medical devices show great potential for applications requiring medical care over well-defined periods of time. Such implants naturally degrade and resorb in the body, which eliminates adverse long-term effects or the need for a s ...

EPFL2020

Quasi-Digital Biosensor-Interface for a Portable Pen to Monitor Anaesthetics Delivery

Sandro Carrara, Danilo Demarchi, Francesca Stradolini, Simone Aiassa, Abuduwaili Tuoheti

Monitoring of patient response to the anaesthetic drugs is an attractive improvement for achieving a correct balance of sedation level, increasing the chance of success in the right procedure of anaesthesia. Nowadays, there are no commercial tools able to ...

IEEE2019

Live Demonstration: Quasi-Digital Portable Pen to Monitor Anaesthetics Delivery

Sandro Carrara, Danilo Demarchi, Simone Aiassa, Francesco Grassi

The live demonstration presents the innovative concept of a portable pen-device able to sense anaesthetic compounds over time for improved anaesthesiology practice. A custom Printed Circuit Board (PCB) manage in the event-based quasi-digital domain the sam ...

IEEE2019

IoT Bio-Electronic Multi-Panel Device for On-line Monitoring of Anaesthesia Delivery

Francesca Stradolini

After a failure of "One-Size-Fits-All" approach on traditional treatment of diseases, the age of multi-faceted personalized medicine came into being for tailoring therapy to get the best response in the highest safety margin. Personalized drug dosage is on ...

EPFL2018

Raspberry-Pi based system for propofol monitoring

Sandro Carrara, Danilo Demarchi, Francesca Stradolini, Tugba Kilic, Abuduwaili Tuoheti

Induction of anesthesia with propofol is a largely adopted technique in hospital environments. The correct dosage of this compound is essential to avoid under- or over-anesthesia that may result in serious side-effects. Therefore, in clinical settings, lon ...

ELSEVIER SCIENCE BV2018

Diazepam actions in the VTA enhance social dominance and mitochondrial function in the nucleus accumbens by activation of accumbal dopamine D1 receptors

Maria del Carmen Sandi Perez, Carlos Canto Alvarez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Laura Lozano Montes, Marie-Isabelle Guillot de Suduiraut

Benzodiazepines can ameliorate social disturbances and increase social competition, particularly in high-anxious individuals. However, the neural circuits and mechanisms underlying benzodiazepines’ effects in social competition are not understood. Convergi ...

Nature Publishing Group2018

Cleaning strategy for carbon-based electrodes: Long-term propofol monitoring in human serum

Giovanni De Micheli, Giovanni Boero, Irene Taurino, Francesca Stradolini, Tugba Kilic

In this work, we present a novel electrochemical cleaning procedure for long-term electrochemical monitoring of propofol by using boron-doped diamond (BDD) and pencil graphite electrode (PGE). Propofol is an anesthetic that is widely used for long-lasting ...

Elsevier2018

Performance of Carbon Nano-Scale Allotropes in Detecting Midazolam and Paracetamol in Undiluted Human Serum

Giovanni De Micheli, Sandro Carrara, Irene Taurino, Francesca Stradolini, Ioulia Tzouvadaki, Nima Aliakbarinodehi, Sattar Akbari Nakhjavani

Nano-materials are highly exploited to enhance sensing performance of electrochemical electrodes by increasing the Electro-Active Surface Area (EASA). In this work, an analytical calculation of the deposited EASA is presented and experimentally validated b ...

2018

Energy metabolism in the rat cortex under thiopental anaesthesia measured

João Miguel das Neves Duarte, Rolf Gruetter, Nathalie Just, Sarah Catherine Sonnay

Barbiturates, commonly used as general anaesthetics, depress neuronal activity and thus cerebral metabolism. Moreover, they are likely to disrupt the metabolic support of astrocytes to neurons, as well as the uptake of nutrients from circulation. By employ ...

Wiley-Blackwell2017

Designing Safer Analgesics via mu-Opioid Receptor Pathways

Shuguang Yuan

Pain is both a major clinical and economic problem, affecting more people than diabetes, heart disease, and cancer combined. While a variety of prescribed or over-the-counter (OTC) medications are available for pain management, opioid medications, especial ...

Elsevier Science London2017

Towards 3D facial morphometry : facial image analysis applications in anesthesiology and 3D spectral nonrigid registration

Gabriel Louis Cuendet

In anesthesiology, the detection and anticipation of difficult tracheal intubation is crucial for patient safety. When undergoing general anesthesia, a patient who is unexpectedly difficult to intubate risks potential life-threatening complications with po ...

EPFL2017

Computational design of environmental sensors for the potent opioid fentanyl

Kai Johnsson, Luc Reymond

We describe the computational design of proteins that bind the potent analgesic fentanyl. Our approach employs a fast docking algorithm to find shape complementary ligand placement in protein scaffolds, followed by design of the surrounding residues to opt ...

Elife Sciences Publications Ltd2017

Cascaded PID controller for anaesthesia delivery

Alena Simalatsar

The technologies for continuous measurement of the anaesthetic agents circulating in body fluids are not mature yet, though some preliminary prototypes exist already. We present a control algorithm that based on the real measurement of propofol plasma conc ...

2016

Medial Forebrain Bundle Deep Brain Stimulation has Symptom-specific Anti-depressant Effects in Rats and as Opposed to Ventromedial Prefrontal Cortex Stimulation Interacts With the Reward System

Background: In recent years, deep brain stimulation (DBS) has emerged as a promising treatment option for patients suffering from treatment-resistant depression (TRD). Several stimulation targets have successfully been tested in clinical settings, includin ...

Elsevier Science Inc2015

A streamlined search technology for identification of synergistic drug combinations

Paul Joseph Dyson, Hubert van den Bergh, Patrycja Nowak-Sliwinska, Andrea Brett Gasser

A major key to improvement of cancer therapy is the combination of drugs. Mixing drugs that already exist on the market may offer an attractive alternative. Here we report on a new model-based streamlined feedback system control (s-FSC) method, based on a ...

Nature Publishing Group2015

Facial Image Analysis for Fully-Automatic Prediction of Difficult Endotracheal Intubation

Jean-Philippe Thiran, Matteo Sorci, Anil Yuce, Hua Gao, Gabriel Louis Cuendet

Goal: Difficult tracheal intubation is a major cause of anesthesia related injuries with potential life threatening complications. Detection and anticipation of difficult airway in the preoperative period is thus crucial for the patients’ safety. We propos ...

Institute of Electrical and Electronics Engineers2015