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Related publications (28)

Rapid optimization of drug combinations for the optimal angiostatic treatment of cancer

Hubert van den Bergh, Paul Joseph Dyson, Patrycja Nowak-Sliwinska

Drug combinations can improve angiostatic cancer treatment efficacy and enable the reduction of side effects and drug resistance. Combining drugs is non-trivial due to the high number of possibilities. We applied a feedback system control (FSC) technique w ...

2015

Dual orexin receptor antagonists - promising agents in the treatment of sleep disorders

Damien Lapray

Insomnia is a serious medical and social problem, its prevalence in the general population ranges from 9 to 35% depending on the country and assessment method. Often, patients are subject to inappropriate and therefore dangerous pharmacotherapies that incl ...

Cambridge Univ Press2014

In Vivo Testing of a Novel Adjustable Glaucoma Drainage Device

André Mermoud, Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. We report on the in vivo testing of a novel noninvasively adjustable glaucoma drainage device (AGDD), which features an adjustable outflow resistance, and assess the safety and efficiency of this implant. METHODS. Under general anesthesia, the AGD ...

Association for Research in Vision and Ophthalmology2014

Effects of Isoflurane Anesthesia on Aortic Compliance and Systemic Hemodynamics in Compliant and Noncompliant Aortas

Nikolaos Stergiopoulos

Objectives: To investigate the effect of general anesthesia on aortic compliance and other cardiovascular hemodynamics in chronically instrumented pigs with compliant and noncompliant (stiff) aortas. Design: Experimental study. Setting: University animal l ...

W B Saunders Co-Elsevier Inc2013

Inferring about individual drug and schizotypy effects on cognitive functioning in polydrug using mephedrone users before and after clubbing

Christine Mohr, Daniela Herzig

Objective Mephedrone has been recently made illegal in Europe, but little empirical evidence is available on its impact on human cognitive functions. We investigated acute and chronic effects of mephedrone consumption on drug-sensitive cognitive measures, ...

Wiley-Blackwell2013

Automatic Mallampati Classification Using Active Appearance Models

Jean-Philippe Thiran, Matteo Sorci, Gabriel Louis Cuendet, Anil Yuce

Difficult tracheal intubation assessment is an important research topic in anesthesia as failed intubations are important causes of mortality in anesthetic practice. The modified Mallampati score is widely used, alone or in conjunction with other criteria, ...

2012

Deep thiopental anesthesia alters steady-state glucose homeostasis but not the neurochemical profile of rat cortex

Rolf Gruetter, Hongxia Lei

Barbiturates are regularly used as an anesthetic for animal experimentation and clinical procedures and are frequently provided with solubilizing compounds, such as ethanol and propylene glycol, which have been reported to affect brain function and, in the ...

Wiley-Blackwell2010

Modeling the effects of midazolam on cortical and thalamic neurons

Sean Lewis Hill

Controversy exists regarding the site where anesthetics act in the brain to produce sedation and unconsciousness. Actions in the cerebral cortex and thalamus are likely, although the relative importance of each site is unclear. We used in computo modeling ...

2009

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