Laboratoire de biophysique statistique

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Solving native structures of such large molecules, like biomolecules, is often challenging, particularly due to the potentially infinite number of non-covalent interactions with water. In this thesis, we report the use of cold ion gas-phase action spectros ...

The present application relates to a computer-implemented systems and methods for protein interaction design using surface fingerprints. The method comprises predicting at least one target interface site with high binding propensity, wherein, optionally, t ...

The Hsp70 cycle is a key element of protein homeostasis, which is essential to avoid protein aggregation and protein-related diseases. Despite many experimental observations of the interaction between Hsp70, its co-chaperone DnaJ and various substrates, li ...

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

We develop techniques to study the phase transition for planar Gaussian percolation models that are not (necessarily) positively correlated. These models lack the property of positive associations (also known as the 'FKG inequality'), and hence many classi ...

TAR DNA-binding protein with 43 kD (TDP-43) is a partially disordered protein that misfolds and accumulates in the brains of patients affected by several neurodegenerative diseases. TDP-43 oligomers have been reported to form due to aberrant misfolding or ...

The present invention relates to a computer-implemented method for engineering the interaction between a protein and a cognate peptide that are capable of forming a molecular complex, wherein the method comprises (a) preparing in silico a library of test p ...

The sheer size of the protein sequence space is massive: a protein of 100 residues can have 20^100 possible sequence combinations; and knowing that this exceeds the number of atoms in the universe, the chance of randomly discovering a stable new sequence w ...

Laboratoire de biophysique statistique

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Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy

Systems and methods for de novo design of protein interactions with learned surface fingerprints

Why do we need so many proteins? A physical insight into the collaboration of Hsp70 and DnaJ

De novo design of protein interactions with learned surface fingerprints

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

THE PHASE TRANSITION FOR PLANAR GAUSSIAN PERCOLATION MODELS WITHOUT FKG

Recombinant Full-Length TDP-43 Oligomers Retain Their Ability to Bind RNAs, Are Not Toxic, and Do Not Seed TDP-43 Aggregation in Vitro

Computer-implemented design of peptide:receptor signaling complexes for enhanced chemotaxis

Towards automating de novo protein design for novel functionalities: controlling protein folds and protein-protein interactions