Sos1 ablation alters focal adhesion dynamics and increases Mmp2/9-dependent gelatinase activity in primary mouse embryonic fibroblasts

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Molecular characterization of an adhesion GPCR signal transduction using Graph-neural networks

Matthieu François Marfoglia

Key cellular functions depend on the transduction of extracellular mechanical signals by specialized membrane receptors, including adhesion G-protein coupled receptors (aGPCRs). While recent structural studies support aGPCR activation through shedding of t ...

EPFL2025

Rational design of small-molecule responsive protein switches

Bruno Emanuel Ferreira De Sousa Correia, Leo Scheller, Sailan Shui, Stephen Michael Buckley

Small-molecule responsive protein switches are powerful tools for controlling cellular processes. These switches are designed to respond rapidly and specifically to their inducer. They have been used in numerous applications, including the regulation of ge ...

2023

KRAB zinc finger protein ZNF676 controls the transcriptional influence of LTR12-related endogenous retrovirus sequences

Didier Trono, Priscilla Turelli, Alexandre Louis André Persat, Julien Léonard Duc, Alexandre Coudray, Michaël Imbeault, Tamara Rossy, Delphine Yvette L Grun, Alexandra Iouranova, Jonas Caspar De Tribolet-Hardy

Background Transposable element-embedded regulatory sequences (TEeRS) and their KRAB-containing zinc finger protein (KZFP) controllers are increasingly recognized as modulators of gene expression. We aim to characterize the contribution of this system to g ...

2022

Identification of epidermal pdx1 expression discloses different roles of notch1 and notch2 in murine kras-induced skin carcinogenesis in vivo

Freddy Radtke

BACKGROUND: The Ras and Notch signaling pathways are frequently activated during development to control many diverse cellular processes and are often dysregulated during tumorigenesis. To study the role of Notch and oncogenic Kras signaling in a progenitor ...

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