Publications associées à Design and modelling of a compliant constant-force surgical tool for objective assessment of ossicular chain mobility

First paleoproteome study of fossil fish otoliths and the pristine preservation of the biomineral crystal host

Anders Meibom, Jaroslaw Hubert Stolarski, Jinming Guo

Otoliths are calcium carbonate components of the stato-acoustical organ responsible for hearing and maintenance of the body balance in teleost fish. During their formation, control over, e.g., morphology and carbonate polymorph is influenced by complex ins ...

Nature Portfolio2023

Efficient viral transduction in mouse inner ear hair cells with utricle injection and AAV9-PHP.B

Bernard Schneider, Paola Andrea Solanes Vega

Viral delivery of exogenous coding sequences into the inner ear has the potential for therapeutic benefit for patients suffering genetic or acquired hearing loss. To devise improved strategies for viral delivery, we investigated two injection techniques, r ...

2020

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Sofia Carmen Suzanne Spataro, Paola Andrea Solanes Vega

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

2019

Bulged Eardrum Detection From 3D Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

Bulging is a medical characteristic of the eardrum that is crucial for the diagnosis of acute otitis media. This work proposes a novel classification method for distinguishing bulged eardrums from non-bulged ones. The method uses novel key features extract ...

IEEE2018

Automated Eardrum Registration From Light-Field Data

Pascal Frossard, Ivana Tosic, Sofia Karygianni

The performance of automated classification algorithms for medical images needs to be very high and especially robust in order to be adopted into healthcare. Most of the time the main challenge is unregistered data, since it is usually captured: 1) from di ...

IEEE2018

Optical proximity sensing system for atraumatic cochea implant surgery

Demetri Psaltis, Ye Pu, Christophe Moser, Ye Pu

The design of a proximity sensor to be integrated into cochlea implants is described. The sensor allows the anticipation of contact between the cochlear implant and intracochlear structures, including the cochlear canal wall and basilar membrane, providing ...

2017

Surgical Anatomy of the Human Round Window Region: Implication for Cochlear Endoscopy Through the External Auditory Canal

Simon Nessim Henein, Demetri Psaltis

Objective: To enable development of an endoscope for cellular-level optical imaging of the inner ear. Study Design: A prospective study of 50 cadaveric human temporal bones to define detailed surgical anatomy of the round window (RW) region and the range o ...

Lippincott, Williams & Wilkins2016

Objective and subjective validation of an active control approach to reduce the occlusion effect in hearing aids

Hervé Lissek, Thomas Stefan Zurbrügg

The occlusion effect refers to the altered perception of one's own voice when the ear canal is fully or partially obstructed. Conventional countermeasures include the use of large vent bores or open fittings on the one hand and fittings reaching as deep as ...

S Hirzel Verlag2015

Abrogation of HMX1 Function Causes Rare Oculoauricular Syndrome Associated With Congenital Cataract, Anterior Segment Dysgenesis, and Retinal Dystrophy

PURPOSE. To define the phenotypic manifestation, confirm the genetic basis, and delineate the pathogenic mechanisms underlying an oculoauricular syndrome (OAS). METHODS. Two individuals from a consanguineous family underwent comprehensive clinical phenotyp ...

Assoc Research Vision Ophthalmology Inc2015

Active Control mitigating the Ear Canal Occlusion Effect caused by Hearing Aids

Thomas Stefan Zurbrügg

The World Health Organization (WHO) estimates the prevalence of a disabling hearing loss to be above 5% world-wide 1. A treatment with a hearing aid - be it behind-the-ear (BTE), in-the-ear (ITE) or receiver-in-canal (RIC) - involves some degree of occlusi ...

EPFL2014

Investigations on the physical factors influencing the ear canal occlusion effect caused by hearing aids

Hervé Lissek, Thomas Stefan Zurbrügg

The occlusion effect refers to the altered perception of one's own voice when the ear canal is fully or partially obstructed. While the loudness increase due to body conducted sounds requires an assessment by psychoacoustic methods, the ratio of sound pres ...

Hirzel Verlag2014

Two-photon microscopy of the mouse cochlea in situ for cellular diagnosis

Demetri Psaltis, Chia-Lung Hsieh, Ye Pu, Xin Yang, Ye Pu

Sensorineural hearing loss is the most common type of hearing loss worldwide, yet the underlying cause is typically unknown because the inner ear cannot be biopsied today without destroying hearing, and intracochlear cells have not been imaged with resolut ...

SPIE Society of Photo-optical Instrumentation Engineers2013

Normal Dendritic Cell Mobilization to Lymph Nodes under Conditions of Severe Lymphatic Hypoplasia

Melody Swartz, Joseph Rutkowski

To address the requirement for lymphatic capillaries in dendritic cell (DC) mobilization from skin to lymph nodes (LNs), we used mice bearing one inactivated allele of vascular endothelial growth factor receptor 3 (VEGFR3) where skin lymphatic capillaries ...

American Association of Immunologists ; Oxford University Press2013

Tissue and cellular imaging

Demetri Psaltis, Chia-Lung Hsieh, Ye Pu, Xin Yang, Ye Pu

Systems and methods for imaging ear tissue include: directing illumination radiation to pass through an intact biological structure and be incident on ear tissue that does not include an exogenous fluorophore, at a plurality of locations, the illumination ...

2013

Design of a Semi-Implantable Hearing Device for Direct Acoustic Cochlear Stimulation

Hans Bernhard, Yves Perriard

A new hearing therapy based on direct acoustic cochlear stimulation was developed for the treatment of severe to profound mixed hearing loss. The device efficacy was validated in an initial clinical trial with four patients. This semi-implantable investiga ...

Institute of Electrical and Electronics Engineers2011

Potential novel drug carriers for inner ear treatment: hyperbranched polylysine and lipid nanocapsules

Harm-Anton Klok, Markus Scholl, Zuzana Kadlecova

Aim: Treatment of sensorineural hearing loss could be advanced using novel drug carriers such as hyperbranched polylysine (HBPL) or lipid nanocapsules (LNCs). This study examined HBPL and LNCs for their cellular uptake and possible toxicity in vitro and in ...

Future Medicine2009

Mutation in the human homeobox gene NKX5-3 causes an oculo-auricular syndrome

Several dysmorphic syndromes affect the development of both the eye and the ear, but only a few are restricted to the eye and the external ear. We describe a developmental defect affecting the eye and the external ear in three members of a consanguineous f ...

2008