Publication

Higher generation cationic N,N-ruthenium(II)-ethylene-glycol-derived metallodendrimers: Synthesis, characterization and cytotoxicity

Publications associées (27)

Anticancer activity of new organo-ruthenium, rhodium and iridium complexes containing the 2-(pyridine-2-yl)thiazole N,N-chelating ligand

Paul Joseph Dyson, Angela Casini, Fabio Edafe

The dinuclear dichloro complexes [(η6-arene)2Ru2(μ-Cl)2Cl2] and [(η5-C5Me5)2M2(μ-Cl)2Cl2] react with 2-(pyridine-2-yl)thiazole (pyTz) to afford the cationic complexes [(η6-arene)Ru(pyTz)Cl]+ (arene = C6H6 (1), p-iPrC6H4Me (2) or C6Me6 (3)) and [(η5-C5Me5)M ...

Elsevier2010

Novel Ruthenium Complexes with Sterically Demanding Cyclopentadienyl Ligands : Syntheses, Reactivity and Catalytic Applications

Barnali Dutta

Investigations of ruthenium halfsandwich complexes have mostly focused on Cp and Cp* based derivatives due to the availability of easily accessible starting materials. However, it is interesting to have complexes with substituted cyclopentadienyl ligands i ...

EPFL2010

Isomerization Mechanisms of Stereolabile tris- and bis-Bidentate Octahedral Cobalt(II) Complexes: X-ray Structure and Variable Temperature and Pressure NMR Kinetic Investigation

André Merbach, Lothar Helm, Rosario Scopelliti, Fabrice Riblet

The isomerization dynamics of five labile octahedral Co(II) compounds have been investigated by variable temperature and pressure 1H and 19F NMR spectroscopy in dichloromethane solution. The X-ray crystal structure of the two tris-chelates, [Co(HFA)2bpic] ...

American Chemical Society2010

Metabolization of [Ru(η6-C6H5CF3)(pta)Cl2]: a cytotoxic RAPTA-type complex with a strongly electron withdrawing arene ligand

Paul Joseph Dyson, Anna Katherine Renfrew, Christian Hartinger

The anticancer ruthenium-arene compd. [Ru(η6-C6H5CF3)(pta)Cl2] (pta = 1,3,5-triaza-7-phosphatricyclo[3.3.1.1]decane), termed RAPTA-CF3, with the electron-withdrawing α,α,α-trifluorotoluene ligand, is one of the most cytotoxic RAPTA compds. known. To ration ...

Springer-Verlag2010

Ultrafast X-ray and Optical Spectroscopy of Binuclear Molecular Complexes

Renske Marjan van der Veen

In this thesis we followed the synergetic approach of combining ultrafast optical and X-ray spectroscopies to unravel the electronic and geometric structural dynamics of the solvated binuclear transition metal complex [Pt2(P2O5H2)4] 4- (PtPOP). This molecu ...

EPFL2010

Binding of Organometallic Ruthenium(II) Anticancer Compounds to Nucleobases: A Computational Study

Ursula Röthlisberger, Ivano Tavernelli, Christian Gossens

The reaction of the anticancer compound (eta(6)-benzene)Ru(en)(OH2) (1) toward the nucleobases guanine, adenine, and cytosine is studied computationally using DFT/BP86 calculations. The aqua leaving group of such compounds is known to undergo ligand ...

2009

Chelating NHC Ruthenium(II) Complexes as Robust Homogeneous Hydrogenation Catalysts

Gabor Laurenczy, Antonia Neels

A series of ruthenium(II) N-heterocyclic carbene chelate complexes were prepd. by using bidentate chelating alkene-carbene, thioether-carbene, carboxylate-carbene and bis-carbene ligands. Metalation of 1-R-3-X-imidazolium salts (1-3, R = Me, X = allyl, MeS ...

2009