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Diamond-based microelectrode arrays were fabricated by using nanocrystalline diamond as an insulating layer and conductive boron-doped in order to used them for analysis of brain cortical slices. MEA surface is solely composed of diamond, exposed to the cells. The impedance measurements showed negligible cross-talk between neighbouring diamond microelectrodes. Local field potentials related to neural signals were then successfully recorded from pharmacologically disinhibited rat cortical tissue slices, mechanically coupled on the surface of the MEA. The background signal level of the diamond MEAs was found to be lower than commercial Pt-based MEAs, under identical measurement conditions.
Alexander Mathis, Alberto Silvio Chiappa, Alessandro Marin Vargas, Axel Bisi
Henry Markram, Felix Schürmann, Matthias Wolf, Daniel Keller, Eilif Benjamin Muller, Werner Alfons Hilda Van Geit, Michael Reimann, Srikanth Ramaswamy, James Gonzalo King, Alexis Arnaudon, András Ecker, Jean-Denis Georges Emile Courcol, Armando Romani, Pramod Shivaji Kumbhar, Rajnish Ranjan, Giuseppe Chindemi, Fernando Joaquim Leite Pereira, Christian Andreas Rössert, Michael Emiel Gevaert, Judit Planas Carbonell, Omar Awile, James Bryden Isbister, Daniela Egas Santander, Mustafa Anil Tuncel, Sirio Bolaños Puchet, Maria Reva, Natali Barros Zulaica, Samuel Lieven D. Lapere, Christoph Pokorny, Elvis Boci, Joni Henrikki Herttuainen, Genrich Ivaska, Tanguy Pierre Louis Damart, Vishal Sood, Darshan Mandge, Thomas Brice Delemontex, Aleksandra Zuzanna Teska, Polina Litvak, Jorge Blanco Alonso, Alexander Dietz, Gianluca Ficarelli, Weina Ji
Mahmut Selman Sakar, Lorenzo Francesco John Noseda