Imaging hair cells through laser-ablated cochlear bone

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Inspired by the prominent theory suggesting that auditory-verbal hallucinations (AVH) - the sensation of hearing voices without present speakers - arise as misattribution of inner speech towards external agents, my thesis revolved around self-voice percept ...

Fluorescence lifetime imaging (FLI) is increasingly recognized as a powerful tool for biochemical and cellular investigations, including in vivo applications. Fluorescence lifetime is an intrinsic characteristic of any fluorescent dye which, to a large ext ...

Fiber endoscopy plays an important role in the clinical diagnosis and treatment processes involved in modern medicine. Thin fiber probes can relay information from confined places in the human body that are inaccessible for conventional bulky microscopes. ...

Cladding of a Zr-based metallic glass (MG) on an aluminum substrate was conducted using a layer-wise laser additive manufacturing (AM) method, leading to relative densities higher than 99%. The thickness of the cladding was about 300 μm. The effect of lase ...

We consider a Gross-Pitaevskii equation which appears as a model in the description of dipolar Bose-Einstein condensates, without a confining external trapping potential. We describe the asymptotic dynamics of solutions to the corresponding Cauchy problem ...

Quantum state-resolved scattering experiments for methane molecules colliding with a catalytically active nickel surface are compared to scattering from a nickel surface passivated by a single layer of graphene. The vibrational state distribution of the sc ...

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the p ...

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the f ...

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

Imaging hair cells through laser-ablated cochlear bone

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Dissecting self-voice perception: From bone conduction to robotically-induced self-other voice misattribution in healthy listeners

Single-Photon, Time-Gated, Phasor-Based Fluorescence Lifetime Imaging through Highly Scattering Medium

Wavefront shaping and deep learning in fiber endoscopy

Laser coating of a Zr-based metallic glass on an aluminum substrate

Mass-Energy threshold dynamics for dipolar Quantum Gases

State-to-state methane-surface scattering as a probe of catalytic activity

Biomedical optical techniques for intracochlear cellular imaging

Inner ear cellular imaging through scattering bone

Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice