Publication

Imaging hair cells through laser-ablated cochlear bone

Publications associées (31)

Dissecting self-voice perception: From bone conduction to robotically-induced self-other voice misattribution in healthy listeners

Inspired by the prominent theory suggesting that auditory-verbal hallucinations (AVH) - the sensation of hearing voices without present speakers - arise as misattribution of inner speech towards external agents, my thesis revolved around self-voice percept ...

EPFL2020

Single-Photon, Time-Gated, Phasor-Based Fluorescence Lifetime Imaging through Highly Scattering Medium

Claudio Bruschini, Edoardo Charbon, Arin Can Ülkü

Fluorescence lifetime imaging (FLI) is increasingly recognized as a powerful tool for biochemical and cellular investigations, including in vivo applications. Fluorescence lifetime is an intrinsic characteristic of any fluorescent dye which, to a large ext ...

AMER CHEMICAL SOC2020

Wavefront shaping and deep learning in fiber endoscopy

Eirini Kakkava

Fiber endoscopy plays an important role in the clinical diagnosis and treatment processes involved in modern medicine. Thin fiber probes can relay information from confined places in the human body that are inaccessible for conventional bulky microscopes. ...

EPFL2020

Laser coating of a Zr-based metallic glass on an aluminum substrate

Stefano Mischler, Jamasp Jhabvala, Alejandro Roda Buch, Roland Logé, Navid Sohrabi

Cladding of a Zr-based metallic glass (MG) on an aluminum substrate was conducted using a layer-wise laser additive manufacturing (AM) method, leading to relative densities higher than 99%. The thickness of the cladding was about 300 μm. The effect of lase ...

2020

Mass-Energy threshold dynamics for dipolar Quantum Gases

Luigi Forcella

We consider a Gross-Pitaevskii equation which appears as a model in the description of dipolar Bose-Einstein condensates, without a confining external trapping potential. We describe the asymptotic dynamics of solutions to the corresponding Cauchy problem ...

2022

State-to-state methane-surface scattering as a probe of catalytic activity

Rainer Beck, Maarten Eduard van Reijzen, Jörn Werdecker, Bo-Jung Chen

Quantum state-resolved scattering experiments for methane molecules colliding with a catalytically active nickel surface are compared to scattering from a nickel surface passivated by a single layer of graphene. The vibrational state distribution of the sc ...

2020

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Selective femtosecond laser ablation via two-photon fluorescence imaging through a multimode fiber

Demetri Psaltis, Christophe Moser, Damien Claude-Marie Loterie, Donald Benjaman Conkey, Marilisa Romito, Eirini Kakkava

We demonstrate the ability of a multimode fiber probe to provide two-photon fluorescence (TPF) imaging feedback that guides the femtosecond laser ablation (FLA) in biological samples for highly selective modifications. We implement the system through the p ...

OPTICAL SOC AMER2019

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Nicolas Vachicouras, Stéphanie Lacour

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the f ...

2019

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Sofia Carmen Suzanne Spataro, Paola Andrea Solanes Vega

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019