Publication

Perception of Auditory Distance in Normal-Hearing and Moderate-to-Profound Hearing-Impaired Listeners

Publications associées (30)

Delivery of CRISPR/Cas9 using AAV-PHP.B in the inner ear leads to allele-specific inactivation of the mutated Tmc1 allele and protects auditory function in Beethoven mice

Bernard Schneider, Sofia Carmen Suzanne Spataro, Paola Andrea Solanes Vega

Hearing Loss (HL) is the most prevalent sensorineural disorder, affecting 360 million people worldwide. As genetic causes lead to 50% of pre-lingual deafness, gene therapy is considered as a potential therapeutic strategy. Mutations in the TMC1 gene are li ...

MARY ANN LIEBERT, INC2019

Inner ear cellular imaging through scattering bone

Demetri Psaltis, Marilisa Romito

Inner ear imaging is important for the assessment of hearing disorders. A major cause of hearing loss is the damage to the sensory hair cells, which are located inside the cochlea, a spiral-shaped bone in the inner ear. Imaging of intracochear hair cells i ...

SPIE-INT SOC OPTICAL ENGINEERING2019

Circadian Regulation of Cochlear Sensitivity to Noise by Circulating Glucocorticoids

Frédéric Bruno Martin Gachon, Benjamin Dieter Weger

The cochlea possesses a robust circadian clock machinery that regulates auditory function. How the cochlear clock is influenced by the circadian system remains unknown. Here, we show that cochlear rhythms are system driven and require local Bmal1 as well a ...

2019

Biomedical optical techniques for intracochlear cellular imaging

Marilisa Romito

Imaging the inner ear microanatomy is of great importance for the assessment of the state of the cells responsible for sound detection. Hearing disorders are mainly due to a malfunction of the cochlea, the bone containing the cells inside the inner ear. Un ...

EPFL2019

Imaging hair cells through laser-ablated cochlear bone

Demetri Psaltis, Ye Pu, Marilisa Romito

We report an innovative technique for the visualization of cells through an overlying scattering medium by combining femtosecond laser bone ablation and two-photon excitation fluorescence (TPEF) microscopy. We demonstrate the technique by imaging hair cell ...

2019

ArASL: Arabic Alphabets Sign Language Dataset

Mohammad Khaja Nazeeruddin

A fully-labelled dataset of Arabic Sign Language (ArSL) images is developed for research related to sign language recognition. The dataset will provide researcher the opportunity to investigate and develop automated systems for the deaf and hard of hearing ...

2019

Auditory Brainstem Implants: Recent Progress and Future Perspectives

Nicolas Vachicouras, Stéphanie Lacour

The auditory brainstem implant (ABI) was first developed nearly 40 years ago and provides auditory rehabilitation to patients who are deaf and ineligible for cochlear implant surgery due to abnormalities of the cochlea and cochlear nerve. The aims of the f ...

2019

Fingerprinting Big Data: The Case of KNN Graph Construction

Rachid Guerraoui, Anne-Marie Kermarrec, Olivier Ruas

We propose fingerprinting, a new technique that consists in constructing compact, fast-to-compute and privacy-preserving binary representations of datasets. We illustrate the effectiveness of our approach on the emblematic big data problem of K-Nearest-Nei ...

2019

Microstructured thin-film electrode technology enables proof of concept of scalable, soft auditory brainstem implants

Nicolas Vachicouras, Florian Dylan Fallegger, Stéphanie Lacour, Christina Myra Tringides, Jennifer Mary Adrienne Alice Macron, Yohann Daniel André Thenaisie, Valentina Marie Paggi

Auditory brainstem implants (ABIs) provide sound awareness to deaf individuals who are not candidates for the cochlear implant. The ABI electrode array rests on the surface of the cochlear nucleus (CN) in the brainstem and delivers multichannel electrical ...

2019

Effects of Binaural Spatialization in Wireless Microphone Systems for Hearing Aids on Normal-Hearing and Hearing-Impaired Listeners

Xavier Gigandet, Hervé Lissek, Gilles André Courtois

Little is known about the perception of artificial spatial hearing by hearing-impaired subjects. The purpose of this study was to investigate how listeners with hearing disorders perceived the effect of a spatialization feature designed for wireless microp ...

2018