Publications associées à Joint host-pathogen genomic analysis identifies hepatitis B virus mutations associated with human NTCP and HLA class I variation

Publications associées (9)

Repairing a deleterious domestication variant in a floral regulator gene of tomato by base editing

Giovanna Ambrosini, Nicolas Jean Philippe Guex, Christian Iseli

Crop genomes accumulate deleterious mutations—a phenomenon known as the cost of domestication. Precision genome editing has been proposed to eliminate such potentially harmful mutations; however, experimental demonstration is lacking. Here we identified a ...

2025

Estimated transmission dynamics of SARS-CoV-2 variants from wastewater are unbiased and robust to differential shedding

Tamar Kohn, Timothy R. Julian, Charles Zeng Gan

The COVID-19 pandemic has accelerated the development and adoption of wastewater-based epidemiology. Wastewater samples can provide genomic information for detecting and assessing the spread of SARS-CoV-2 variants in communities and for estimating importan ...

2025

The potential of metal–organic framework MIL-101(Al)–NH2 in the forefront of antiviral protection of cells via interaction with SARS-CoV-2 spike RBD protein and their antibacterial action mediated with hypericin and photodynamic treatment

Georges Wagnières, Jaroslava Joniová

The global pandemic of SARS-CoV-2 has highlighted the necessity for innovative therapeutic solutions. This research presents a new formulation utilising the metal–organic framework MIL-101(Al)–NH2, which is loaded with hypericin, aimed at addressing viral ...

2025

Using viral diversity to identify HIV-1 variants under HLA-dependent selection in a systematic viral genome-wide screen

Jacques Fellay

The pathogenesis of HIV-1 infection is governed by a highly dynamic, time-dependent interaction between the host and the viral genome. In this study, we developed a novel systematic approach to assess the host-virus interaction, using average pairwise vira ...

PUBLIC LIBRARY SCIENCE2024

Students explain evolution by natural selection differently for humans versus nonhuman animals

Joelyn de Lima

Evolution is foundational to understanding biology, yet learners at all stages have incomplete and incorrect ideas that persist beyond graduation. Contextual features of prompts (e.g., taxon of organism, acquisition vs. loss of traits, etc.) have been show ...

Amer Soc Cell Biology2023

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Luqing Li, Michele De Palma, Nahal Mansouri, Ali Ghasemi, Alan Nicolas Thierry Guichard, Yahya Mohammadzadeh, Bruno Torchia

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical re ...

Nature Portfolio2023

Blood virosphere in febrile Tanzanian children

Jacques Fellay, Nicolas Jean Philippe Guex, Mary-Anne Hartley, Christian Iseli, Thomas Junier, Gasser Hassan Elbanna Abdelbaset Abdelrahman Elbanna

Viral infections are the leading cause of childhood acute febrile illnesses motivating consultation in sub-Saharan Africa. The majority of causal viruses are never identified in low-resource clinical settings as such testing is either not part of routine s ...

2021

Discovery and functional characterisation of structural genomic variation in a natural population

Andreas Massouras

EPFL2013

New synthetic seven-membered 1-azasugars displaying potent inhibition towards glycosidases and glucosylceramide transferase

Pierre Vogel, Sylvain Favre

Several members of a new family of seven-membered azasugars, which can be seen as 1-azasugar ring homologues, have been I obtained by simple chemical transformations starting from a sugar-derived azidolactol. Unlike their piperidine counterparts, these mol ...

2008