Publications associées à Cytotoxic profile and peculiar reactivity with biomolecules of a novel “rule-breaker” iodo-platinum(II) complex

A Route to Stabilize Uranium(II) and Uranium(I) Synthons in Multimetallic Complexes

Rosario Scopelliti, Marinella Mazzanti, Ivica Zivkovic, Dieuwertje Katelijn Modder

Herein, we report the redox reactivity of a multimetallic uranium complex supported by triphenylsiloxide (−OSiPh3) ligands, where we show that low valent synthons can be stabilized via an unprecedented mechanism involving intramolecular ligand migration. T ...

Wiley-VCH Verlag GmbH2023

Reduced representations of complexes, signals, and multifiltrations

Celia Camille Hacker

The field of computational topology has developed many powerful tools to describe the shape of data, offering an alternative point of view from classical statistics. This results in a variety of complex structures that are not always directly amenable for ...

EPFL2022

A Mesoionic Diselenolene Anion and the Corresponding Radical Dianion

Andrzej Sienkiewicz, Kay Severin, Rosario Scopelliti, Farzaneh Fadaei Tirani, Abdusalom Suleymanov, Cesare Berton, Zhaowen Dong

Dichalcogenolenes are archetypal redox non-innocent ligands with numerous applications. Herein, we describe a diselenolene ligand with fundamentally different electronic properties. By selenation of a C2-protected imidazolium salt, we have prepared a mesoi ...

2022

On the Grothendieck-Serre conjecture for classical groups

Eva Bayer Fluckiger

We prove some new cases of the Grothendieck-Serre conjecture for classical groups. This is based on a new construction of the Gersten-Witt complex for Witt groups of Azumaya algebras with involution on regular semilocal rings, with explicit second residue ...

WILEY2022

Collapse-invariant properties of spaces equipped with signals or directions

Stefania Ebli

Collapsing cell complexes was first introduced in the 1930's as a way to deform a space into a topological-equivalent subspace with a sequence of elementary moves. Recently, discrete Morse theory techniques provided an efficient way to construct deformatio ...

EPFL2022

Learning the Exciton Properties of Azo-dyes

Anne-Clémence Corminboeuf, Alberto Fabrizio, Sergio Vela Llausi, Ksenia Briling

The ab initio determination of electronic excited state (ES) properties is the cornerstone of theoretical photochemistry. Yet, traditional ES methods become impractical when applied to fairly large molecules, or when used on thousands of systems. Machine l ...

AMER CHEMICAL SOC2021

On the exploration of novel methodological approaches for immunogen design: case studies in influenza and hepatitis C

Andreas Scheck

Proteins are fundamental components in biological systems and crucial for a variety of biological functions. Over the last decades, significant progress in structural biology has facilitated the study of proteins and their interactions with molecular partn ...

EPFL2021

Organohalide respiration in Firmicutes: energy metabolism and transcription regulation

Mathilde Stéphanie Willemin

Organohalides are a class of compounds often considered as persistent pollutants and harmful to environmental and human health. Some bacteria, among which are representatives from the Firmicutes phylum, are capable of using these compounds as terminal acce ...

EPFL2021

Stepwise Reduction of Dinitrogen by a Uranium-Potassium Complex Yielding a U(VI)/U(IV) Tetranitride Cluster

Marinella Mazzanti, Ivica Zivkovic, Farzaneh Fadaei Tirani, Luciano Barluzzi, Nadir Jori

Multimetallic cooperativity is believed to play a key role in the cleavage of dinitrogen to nitrides (N3-), but the mechanism remains ambiguous due to the lack of isolated intermediates. Herein, we report the reduction of the complex [K-2{[U-V(OSi((OBu)-Bu ...

2021

Hierarchical B-spline complexes of discrete differential forms

Rafael Vazquez Hernandez

In this paper, we introduce the hierarchical B-spline complex of discrete differential forms for arbitrary spatial dimension. This complex may be applied to the adaptive isogeometric solution of problems arising in electromagnetics and uid mechanics. We de ...

2020

Catalytic Enantioselective Transformations with Chiral Cyclopentadienyl Ruthenium(II) Complexes

Sung Hwan Park

The chemistry of cyclopentadienyl ruthenium(II) complexes plays an important role in ruthenium catalysis because of its high potential for various transformations. However, asymmetric catalysis with chiral cyclopentadienyl ruthenium(II) complexes is still ...

EPFL2020

Delivery of a Masked Uranium(II) by an Oxide-Bridged Diuranium(III) Complex

Marinella Mazzanti, Farzaneh Fadaei Tirani, Dieuwertje Katelijn Modder

Oxide is an attractive linker for building polymetallic complexes that provide molecular models for metal oxide activity, but studies of these systems are limited to metals in high oxidation states. Herein, we synthesized and characterized the molecular an ...

Wiley-VCH Verlag GmbH2021

Determination and evaluation of the nonadditivity in wetting of molecularly heterogeneous surfaces

Francesco Stellacci, Quy Ong Khac, Sylvie Roke, Zhi Luo, Michele Ceriotti, Filip Kovacik, David Mark Wilkins, Halil Ibrahim Okur, Anna Murello

The interface between water and folded proteins is very complex. Proteins have "patchy" solvent-accessible areas composed of domains of varying hydrophobicity. The textbook understanding is that these domains contribute additively to interfacial properties ...

National Academy of Sciences2019

Advanced characterization methods for self-assembled organization on nanoparticles

Zhi Luo

The complex organizations of amino acid residues on protein surfaces give rise to a wide space of functions for proteins. Great efforts are devoted in biology to understand such structure-property relationships. Many advanced characterization techniques ha ...

EPFL2018

Business Models and Complexity

Christopher Tucci, Lorenzo Massa, Gianluigi Viscusi

Purpose: To offer a -necessarily non-exhaustive- analysis of the meaning and significance of the notion of a complex system for research on the Business Model (BM). Design/Methodology/Approach: Conceptual paper Findings: Drawing from early research in comp ...

2018

Synthesis and Characterization of a Water Stable Uranyl(V) Complex

Rosario Scopelliti, Anne-Sophie Chauvin, Marinella Mazzanti, Radmila Faizova

We have identified a polydentate aminocarboxylate ligand that stabilizes uranyl(V) in water. The mononuclear [UO2(dpaea)]X, (dpaeaH2 = Bis(pyridyl-6-methyl-2-carboxylate)-ethylamine; X = CoCp2*+ or X = K(2.2.2.cryptand) complexes have been isolated from an ...

2018

A Decapeptide Hydrated by Two Waters: Conformers Determined by Theory and Validated by Cold Ion Spectroscopy

Oleg Boyarkine, Natalia Nagornova, Robert Benny Gerber

The intrinsic structures of biomolecules in the gas phase may not reflect their native solution geometries. Microsolvation of the molecules bridges the two environments, enabling a tracking of molecular structural changes upon hydration at the atomistic le ...

American Chemical Society2017

Structural Features of the Box C/D snoRNP Pre-assembly Process Are Conserved through Species

Benjamin Marcel Daniel Rothé

Box C/D small nucleolar ribonucleoparticles (snoRNPs) support 2'-O-methylation of several target RNAs. They share a common set of four core proteins (SNU13, NOP58, NOP56, and FBL) that are assembled on different guide small nucleolar RNAs. Assembly of thes ...

Cell Press2016

Local versus global and retinotopic versus non-retinotopic motion processing in schizophrenia

Michael Herzog, Maya Roinishvili, Marc Michael Lauffs, Albulena Jashari-Shaqiri

Schizophrenia impairs cognitive function as much as perception. For example, patients perceive global motion in random dot kinematograms less strongly, because the integration of the dots into a single Gestalt is complex (e.g., Chen, Nakayama, Levy, Matthy ...

2016

Structural insights on cholesterol endosynthesis: Binding of squalene and 2,3-oxidosqualene to supernatant protein factor

Michele Cascella, Maria Josefina Marcaida Lopez, Christos Lamprakis

We present the crystal structures of the SEC14-like domain of supernatant protein factor (SPF) in complex with squalene and 2,3-oxidosqualene. The structures were resolved at 1.75 angstrom (complex with squalene) and 1.6 angstrom resolution (complex with 2 ...

Elsevier2015