Automated characterization of dextran/concanavalin A mixtures-A study of sensitivity and temperature dependence at low viscosity as basis for an implantable glucose sensor

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Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic beta-cells

Guillaume Jacot

Pancreatic beta-cells secrete insulin to lower blood glucose, following a meal. Maintenance of beta-cell function is essential to preventing type 2 diabetes. In pancreatic beta-cells, mitochondrial matrix calcium is an activating signal for insulin secreti ...

2020

Development of novel tools for imaging of metabolic fluxes in vivo

Tamara Maric

Bioluminescent imaging is a powerful technique that enables imaging in living organisms with high sensitivity, low background signal, low cost and without the need for radioactivity. The emitted photons are produced in the oxidation reaction of luciferin c ...

EPFL2020

Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth

Bernard Lanz, Graham Knott, Rolf Gruetter, Stéphanie Clerc, Nadine Fournier, Caroline Anne-Lyse Contat, Mario Gaetano Lepore, Etienne Meylan, Anders Meibom, Stéphane Laurent Escrig, Justine Pascual, Louise Helene Soegaard Jensen, Pierre-Benoit Bernard Ancey, Silvia Sabatino

Glucose utilization increases in tumors, a metabolic process that is observed clinically by F-18-fluorodeoxyglucose positron emission tomography (F-18-FDG-PET). However, is increased glucose uptake important for tumor cells, and which transporters are impl ...

2020

Effect of Fluid Viscosity on Earthquake Nucleation

Marie Estelle Solange Violay, Chiara Cornelio

Injection of fluids in geo-reservoirs can reduce the effective stresses at depth, lubricating the nearby faults, promoting slip and, potentially, earthquakes. High-viscous fluids are often used during hydraulic fracturing and production phases in geo-reser ...

2020

Pancreatic beta cell based optical biosensor and system for continuous glucose monitoring

Catherine Dehollain, Nicolas Bouche, Christophe Boss, Bakul Jitendra Vinchhi, Ninad Dilip Agashe

A bio-electronics system that measures cytosolic [Ca2+] in vitro in the INS-1E pancreatic beta-cells using a 430 nm excitation light with the excitation wavelength of the probe being at 435 nm was successfully implemented and tested. We transfected the INS ...

IEEE2019

Optical microsystems for genetically engineered biosensors. Case study: Glucose monitoring

Bakul Jitendra Vinchhi

Diabetes is a global epidemic with millions of people dying from it every year. Progress in microelectronics and machine learning has led to a huge number of FDA approvals of devices for continuous monitoring and treatment of diabetes with one product usin ...

EPFL2019

Optical pancreatic beta cell based biosensor, applications and glucose monitoring

Catherine Dehollain, Nicolas Bouche, Christophe Boss, Bakul Jitendra Vinchhi

An optical pancreatic beta-cell based biosensor for measuring cytosolic [Ca2+] is presented in this work. An in vitro bio-electronic system is built for testing various applications and characterizing features of the biosensor. A panoply of applications su ...

IEEE2019

3D-Integration Of Printed Electrochemical Sensors In Pet Microfluidics For Biochemical Sensing

Danick Briand, Peter Van der Wal, Silvia Demuru

This paper presents a novel process for screen printed electrode fabrication, functionalization and integration in a polyethylene terephthalate (PET) fluidics system for electrochemical analysis. The innovative components utilized are: 1. 3D Through-Foil V ...

IEEE2019

Glucose transporter 2 mediates the hypoglycemia-induced increase in cerebral blood flow

Rolf Gruetter, Hongxia Lei

Glucose transporter 2 (Glut2)-positive cells are sparsely distributed in brain and play an important role in the stimulation of glucagon secretion in response to hypoglycemia. We aimed to determine if Glut2-positive cells can influence another response to ...

2019

Role of metabolism and mitochondria during glucose sensing and glucose-induced dysfunction in human pancreatic beta-cells

Isabelle Chareyron

Glucose sensing and regulation of insulin secretion are the two main functions performed by the pancreatic beta-cell. Together these processes contribute to the tight control of blood glucose in our body. Compromising the ability of the beta-cells to prope ...

EPFL2019

Glycogen metabolism is impaired in the brain of male type 2 diabetic Goto‐Kakizaki rats

João Miguel das Neves Duarte, Ana Francisca Leal Silva Soares, Sakura Sophie Nussbaum

Diabetes impacts the central nervous system predisposing to cognitive decline. While glucose is the main source of energy fueling the adult brain, brain glycogen is necessary for adequate neuronal function, synaptic plasticity and memory. In this study, we ...

2019

Protein Bioconjugation to Carbon Nanotubes for Near-Infrared Sensing

Vitalijs Zubkovs

Single-walled carbon nanotubes (SWCNTs) are a promising material for electrochemical and optical biosensing applications. Their small dimensions, large surface area, indefinite photostability, and remarkable electronic properties make SWCNTs an ideal trans ...

EPFL2019