Modulating dynamics and function of nuclear actin with synthetic bicyclic peptides

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Leveraging chromatin modules to explore the impact of regulatory variation on disease

Olga Pushkarev

Human genome is complex and hierarchically organized within the nucleus, where cis-regulatory elements (CREs) frequently interact within topologically associated domains to regulate gene expression. While genomic technologies and computational approaches h ...

EPFL2025

Cell-autonomous timing drives the vertebrate segmentation clock's wave pattern

Andrew Charles Oates, Sundar Ram Naganathan, Daniele Soroldoni, Laurel Ann Rohde, Petr Strnad, Arianne Bercowsky Rama, Guillaume Michel Valentin

Rhythmic and sequential segmentation of the growing vertebrate body relies on the segmentation clock, a multi-cellular oscillating genetic network. The clock is visible as tissue-level kinematic waves of gene expression that travel through the presomitic m ...

2024

S-acylation: an orchestrator of the life cycle and function of membrane proteins

Arthur Samurkas, Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami, Francisco De Magalhães Sarmento Ribeiro De Mesquita

S-acylation is a covalent post-translational modification of proteins with fatty acids, achieved by enzymatic attachment via a labile thioester bond. This modification allows for dynamic control of protein properties and functions in association with cell ...

Wiley2023

Chromophore of an Enhanced Green Fluorescent Protein Can Play a Photoprotective Role Due to Photobleaching

László Forró, Andrzej Sienkiewicz, Katarzyna Pierzchala

Under stress conditions, elevated levels of cellular reactive oxygen species (ROS) may impair crucial cellular structures. To counteract the resulting oxidative damage, living cells are equipped with several defense mechanisms, including photoprotective fu ...

MDPI2021

Biophotonic Tool for Sensing the Dynamics of Oxidative Stress in Living Cells

Olivier Martin, Christian Santschi, Shourya Dutta Gupta, Guillaume Suarez

2012

Specific detection of glycans on a plasma membrane of living cells with atomic force microscopy

Andrzej Kulik

2006