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Proteins drive most cellular functions and are key players in diseases, yet proteomics still lags behind genomics due to the complexity, diversity, and dynamic nature of proteoforms. Nanopore technology – known for real-time, single-molecule DNA sequencing ...
Irbesartan is a non-peptide antagonist of the angiotensin-II-AT1 receptor and is used for the treatment of hypertension. Here, the history, achievements and open questions related to irbesartan are examined. Tautomery of the tetrazole moiety leads to two d ...
The present invention relates generally to the field of anti-cancer therapy, in particular to the use of agents or co-agents useful in anti-cancer immunotherapy such as adoptive T-cell transfer (ACT) immunotherapy and immune check-point blockades. ...