Publication

Autoantibodies against type I IFNs in humans with alternative NF-κB pathway deficiency

Publications associées (31)

The chromatin remodeller Chd7 and the calcium ATPase Serca2 - adding new facets to the role of Notch in Hematopoiesis and T-ALL

Project I: Chd7 Deficiency does not affect N1-driven T-ALL Induction and Maintenance nor impair Hematopoiesis Notch1 has been shown to be a key driver in pediatric T-cell acute lymphobastic leukemia (T-ALL). Previous work in the lab identified the chromati ...

EPFL2015

Memory of tolerance and induction of regulatory T cells by erythrocyte-targeted antigens

Jeffrey Alan Hubbell, Stephane Kontos, Alizée Jéléna Grimm, Xavier Fredy René Quaglia-Thermes, Giacomo Olimpio Diaceri

New approaches based on induction of antigen-specific immunological tolerance are being explored for treatment of autoimmunity and prevention of immunity to protein drugs. Antigens associated with apoptotic debris are known to be processed tolerogenically ...

Nature Publishing Group2015

Default And Systemic Risk In Equilibrium

Martin Larsson

We develop a finite horizon continuous time market model, where risk-averse investors maximize utility from terminal wealth by dynamically investing in a risk-free money market account, a stock, and a defaultable bond, whose prices are determined via equil ...

Wiley-Blackwell2015

Immunomodulatory Roles of Lymphatic Vessels in Cancer Progression

Melody Swartz

Lymphatic vessels in the tumor microenvironment are known to foster tumor metastasis in many cancers, and they can undergo activation, hyperplasia, and lymphangiogenesis in the tumor microenvironment and in the tumor-draining lymph node. The mechanism unde ...

Amer Assoc Cancer Research2014

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

Jeffrey Alan Hubbell, Stephane Kontos, Iraklis Kourtis, Karen Dane

Antigens derived from apoptotic cell debris can drive clonal T-cell deletion or anergy, and antigens chemically coupled ex vivo to apoptotic cell surfaces have been shown correspondingly to induce tolerance on infusion. Reasoning that a large number of ery ...

Natl Acad Sciences2013

TLR4- and TRIF-dependent stimulation of B lymphocytes by peptide liposomes enables T cell-independent isotype switch in mice

Andrea Pfeifer, Marija Vukicevic, Valérie Gafner, Andreas Muhs, Anna Lucia Buccarello, Pedro Miguel Nunes Pereira de Almeida Reis

Immunoglobulin class switching from IgM to IgG in response to peptides is generally T cell-dependent and vaccination in T cell-deficient individuals is inefficient. We show that a vaccine consisting of a dense array of peptides on liposomes induced peptide ...

Amer Soc Hematology2013

Molecular and Functional Characterization of Clonogenic Human Thymic Epithelial Cells

Melissa Maggioni

The thymus is a primary lymphoid organ where bone marrow derived T-cell progenitors come in contact with a unique microenvironment able to sustain their maturation into functional T-cells. This fundamental immunological function of the thymus is supported ...

EPFL2012

Immune Engineering Via Differential Antigen Carriers and Co-Stimulatory Molecules

Jackson Eby

There is an increasing clinical need for vaccines capable of enhancing antigen-specific immune responses and treatments that can induce immunological tolerance toward a single antigen. Here we explore two platforms to enhance either immunization or toleriz ...

EPFL2012

Activation of a glioma-specific immune response by oncolytic parvovirus Minute Virus of Mice infection

Ute Koch

Rodent autonomous parvoviruses (PVs) are endowed with oncotropic properties and represent virotherapeutics with inherent oncolytic features. This work aimed to evaluate the capacity of Minute Virus of Mice (MVMp) to act as an adjuvant stimulating a mouse g ...

2012

A model of risk-sensitive route-choice behaviour and the potential benefit of route guidance

Gunnar Flötteröd

In this paper, we present a simulation-based investigation of the potential benefit of route-guidance information in the context of risk-sensitive travelers. We set up a simple two-route scenario where travelers are repeatedly faced with risky route-choice ...

IEEE Institute of Electrical and Electronics Engineers2011

Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence

Craig Nowell, Xin Jin

The forkhead transcription factor Foxn1 is indispensable for thymus development, but the mechanisms by which it mediates thymic epithelial cell (TEC) development are poorly understood. To examine the cellular and molecular basis of Foxn1 function, we gener ...

Public Library of Science2011