Publications associées à tRNA-derived fragments in T lymphocyte-beta cell crosstalk and in type 1 diabetes pathogenesis in NOD mice

Publications associées (12)

Mammary Intraepithelial Lymphocytes and Intestinal Inputs Shape T Cell Dynamics in Lactogenesis

Siba Smarak Panigrahi, Maurizio Fiusco, Maria Brbic

Pregnancy brings about profound changes in the mammary gland to prepare for lactation, yet immunocyte changes that accompany this rapid remodeling are incompletely understood. We comprehensively analyzed mammary T cells, revealing a marked increase in CD4+ ...

NATURE PORTFOLIO2025

Enhanced TLR7-dependent production of type I interferon by pDCs underlies pandemic chilblains

Jacques Fellay

Outbreaks of chilblains were reported during the COVID-19 pandemic. Given the essential role of type I interferon (I-IFN) in protective immunity against SARS-CoV-2 and the association of chilblains with inherited type I interferonopathies, we hypothesized ...

ROCKEFELLER UNIV PRESS2025

Accessible homeostatic gastric organoids reveal secondary cell type-specific host-pathogen interactions in Helicobacter pylori infections

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Moritz Hofer

Despite the high prevalence of gastric diseases like gastric cancer and peptic ulcer disease attributed to Helicobacter pylori infections, there is still only a limited understanding of the underlying mechanisms. Existing in vitro models are either two-dim ...

NATURE PORTFOLIO2025

Mitochondrial genetics, signalling and stress responses

Johan Auwerx, Jia Liu, Jonathan Allen Sulc

Mitochondria are multifaceted organelles with crucial roles in energy generation, cellular signalling and a range of synthesis pathways. The study of mitochondrial biology is complicated by its own small genome, which is matrilineally inherited and not sub ...

NATURE PORTFOLIO2025

Boosting CAR T-cell therapy through G-protein signal rewiring

Liyan Yang Smeding

Chimeric antigen receptor (CAR) T-cell therapy continues to struggle in reaching its full potential in solid tumors, largely due to the tumor microenvironment (TME) where various small molecules induce immunosuppressive signaling in CAR T-cells. Two key mo ...

EPFL2024

Mitochondrial and NAD plus metabolism predict recovery from acute kidney injury in a diverse mouse population

Johan Auwerx, Maroun Bou Sleiman, Yang Li, Jean-David Horacio Morel, Giacomo Vincenzo Giorgio Von Alvensleben, Alexis Maximilien Bachmann, Dina Hofer

Acute kidney failure and chronic kidney disease are global health issues steadily rising in incidence and prevalence. Animal models on a single genetic background have so far failed to recapitulate the clinical presentation of human nephropathies. Here, we ...

AMER SOC CLINICAL INVESTIGATION INC2023

Dissecting mechanisms of chamber-specific cardiac differentiation and its perturbation following retinoic acid exposure

Matthias Lütolf, Nicolas Antoine Vincent Broguiere, Giuliana Rossi

The specification of distinct cardiac lineages occurs before chamber formation and acquisition of bona fide atrial or ventricular identity. However, the mechanisms underlying these early specification events remain poorly understood. Here, we performed sin ...

COMPANY BIOLOGISTS LTD2022

Advanced Techniques in Optical Diffraction Tomography

Ahmed Bassam Sayed Ayoub Mohamed Emam

In this thesis, we study the 3 challenges described above. First, we study different reconstruction techniques and assess the fidelity of each reconstruction results by means of structured illumination and phase conjugation. By reconstructing the 3D refrac ...

EPFL2022

An Immunomodulatory Gallotanin-Rich Fraction From Caesalpinia spinosa Enhances the Therapeutic Effect of Anti-PD-L1 in Melanoma

Amaia Martinez Usatorre

PD-1/PD-L1 pathway plays a role in inhibiting immune response. Therapeutic antibodies aimed at blocking the PD-1/PD-L1 interaction have entered clinical development and have been approved for a variety of cancers. However, the clinical benefits are reduced ...

FRONTIERS MEDIA SA2020

Mammary epithelial morphogenesis in 3D combinatorial microenvironments

Matthias Lütolf, Mehmet Ugur Girgin

Human mammary epithelial cells can proliferate and reorganize into polarized multi-cellular constructs in-vitro, thereby functioning as an important model system in recapitulating key steps of in-vivo morphogenesis. Current approaches to constructing such ...

NATURE RESEARCH2020

An miRNA-based gene therapy approach to target mutated SOD1 in key cell types in amyotrophic lateral sclerosis (ALS)

Bernard Schneider, Cylia Cloé Rochat, Julianne Bobela, Marie Valérie Vachenka Vilmont

MARY ANN LIEBERT, INC2018

Altered immune responses in mice without initial dermal lymphatics

Melody Swartz, Sachiko Hirosue

Karger2009