Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer's Disease

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The preclinical phase of Alzheimer’s disease represents a crucial time window for therapeutic intervention but requires the identification of clinically relevant biomarkers that are sensitive to the effects of disease-modifying drugs. Amyloid peptide and t ...

Alpha-synuclein (aSyn) post-translational modifications (PTM), especially phosphorylation at serine 129 and C-terminal truncations, are highly enriched in Lewy bodies (LB), Lewy neurites, and other pathological aggregates in Parkinson's disease and synucle ...

Most patients with Parkinson's disease (PD) are not only affected by motor symptoms (e.g., tremor, rigidity, bradykinesia), but also experience hallucinations. Importantly, hallucinations are a risk factor for a more rapid cognitive decline, dementia, and ...

Research in schizophrenia (SZ) emphasizes the need for new therapeutic approaches based on antioxidant/anti-inflammatory compounds and psycho-social therapy. A hallmark of SZ is a dysfunction of parvalbumin-expressing fast-spiking interneurons (PVI), which ...

Huntington's disease is a severe but slowly progressive hereditary illness for which only symptomatic treatments are presently available. Clinical measures of disease progression are somewhat subjective and may require years to detect significant change. T ...

There is an uncountable number of different ways of characterizing almost any given real-world stimulus. This necessitates finding stimulus features that are perceptually relevant - that is, they have distinct and independent effects on the perception and ...

Most of the mechanisms involved in neural plasticity support cognition, and aging has a considerable effect on some of these processes. The neural cell adhesion molecule (NCAM) of the immunoglobulin superfamily plays a pivotal role in structural and functi ...

Cerebrospinal Fluid Proteome Alterations Associated with Neuropsychiatric Symptoms in Cognitive Decline and Alzheimer's Disease

Chattez avec Graph Search

Can brain network connectivity facilitate the clinical development of disease-modifying anti-Alzheimer drugs?

Differential role of C-terminal truncations on alpha-synuclein pathology and Lewy body formation

Sensorimotor and social mechanisms of hallucinations in healthy participants and patients with Parkinson's Disease

Timely N-Acetyl-Cysteine and Environmental Enrichment Rescue Oxidative Stress-Induced Parvalbumin Interneuron Impairments via MMP9/RAGE Pathway: A Translational Approach for Early Intervention in Psychosis

Longitudinal expression changes are weak correlates of disease progression in Huntington's disease

The perceptual relevance of balance, evenness, and entropy in musical rhythms

Age-related cognitive impairments in mice with a conditional ablation of the neural cell adhesion molecule