Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

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The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

We are constantly bombarded by sensory information and constantly making decisions on how to act. In order to optimally adapt behavior, we must judge which sequences of sensory inputs and actions lead to successful outcomes in specific circumstances. Neuro ...

Objective. Peripheral nerve interfaces have the potential to restore sensory, motor, and visceral functions. In particular, intraneural interfaces allow targeting deep neural structures with high selectivity, even if their performance strongly depends upon ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

A low-power digital charge balancing system, which ensures the safe operation of constant-current biphasic stimulation is presented. The concept of the proposed charge-balancing technique is to utilize a hybrid method consisting of anodic pulse modulation ...

Over the past two decades, epidural electrical stimulation (EES) has transitioned from a treatment for chronic pain to a promising paradigm for ameliorating deficits associated with neurological disorders like spinal cord injury (SCI) and Parkinson's Disea ...

Over the last decades, implantable neural interfaces have been extensively explored and effectively deployed to address neurological and mental health disorders. The existing solutions present several limitations. Firstly, the physical size of the implanta ...

"Ensure healthy lives and promote well-being for all at all ages" is the third sustainable development goal for the United Nations Agenda of 2030. This doctoral thesis fully embodied this objective by targeting stroke, a leading cause of death and disabili ...

Multi-polar stimulation protocols have been used in the past to increase the selectivity of electrical stimulation of the nervous system. Nonetheless, the number of possible multipolar stimulation protocols is prohibitively large and cannot be explored dur ...

Although efficient compared to computers, the human brain utilizes energy at 10-fold the rate of other organs by mass. How the brain is supplied with sufficient on-demand energy to support its activity in the absence of neuronal storage capacity remains un ...

Analysis of patient-specific stimulation with segmented leads in the subthalamic nucleus

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Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

Striatal Dopamine Signals and Reward Learning

Combining biophysical models and machine learning to optimize implant geometry and stimulation protocol for intraneural electrodes

Walking naturally after spinal cord injury using a brain-spine interface

Digital One-Shot Charge-balancing Method for Implantable Current-Mode Electrical Stimulation

Closed-Loop Control of Epidural Electrical Stimulation in Patients with Spinal Cord Injury and Parkinson's Disease

Miniaturised, Wireless and Distributed Neural Interface Toward Cortical Visual Prosthesis

Combination of Neurotechnologies Towards Personalized Neurorehabilitation for Stroke Patients

Reconstruction of nerve functional topography using recruitment curves enables selective electrical stimulation

Norepinephrine stimulates glycogenolysis in astrocytes to fuel neurons with lactate