Publication

Gene drives for schistosomiasis transmission control

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Andrea Rinaldo, Francisco Javier Perez Saez, Joseph Chadi Benoit Lemaitre, Jacques Fellay

Following the rapid dissemination of COVID-19 cases in Switzerland, large-scale non-pharmaceutical interventions (NPIs) were implemented by the cantons and the federal government between 28 February and 20 March 2020. Estimates of the impact of these inter ...

2020

Hookworms Evade Host Immunity by Secreting a Deoxyribonuclease to Degrade Neutrophil Extracellular Traps

Manuel Kulagin, Arne Seitz, Nicola Harris, Romain Guiet, Beatrice Volpe, Kathleen Shah, Tiffany Babette Angélique Bouchery, Mati André Marie Moyat

Hookworms cause a major neglected tropical disease, occurring after larvae penetrate the host skin. Neutrophils are phagocytes that kill large pathogens by releasing neutrophil extracellular traps (NETs), but whether they target hookworms during skin infec ...

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The geography of COVID-19 spread in Italy and implications for the relaxation of confinement measures

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The pressing need to restart socioeconomic activities locked-down to control the spread of SARS-CoV-2 in Italy must be coupled with effective methodologies to selectively relax containment measures. Here we employ a spatially explicit model, properly atten ...

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Apparatus for treating excess intraocular fluid having an elastic membrane

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A device (100) is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the device (100) includes a housing shell (101) defining a cavity (107) between a first end (102) and a second end (104) of the housing ...

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Spread and dynamics of the COVID-19 epidemic in Italy: Effects of emergency containment measures

Andrea Rinaldo, Enrico Bertuzzo, Lorenzo Mari, Marino Gatto, Luca Carraro

The spread of coronavirus disease 2019 (COVID-19) in Italy prompted drastic measures for transmission containment. We examine the effects of these interventions, based on modeling of the unfolding epidemic. We test modeling options of the spatially explici ...

National Academy of Sciences2020

Genomic Characterization of Mycobacterium lepraeto Explore Transmission Patterns Identifies New Subtype in Bangladesh

Stewart Cole, Andrej Benjak, Charlotte Avanzi

Mycobacterium leprae, the causative agent of leprosy, is an unculturable bacterium with a considerably reduced genome (3.27 Mb) compared to homologues mycobacteria from the same ancestry. In 2001, the genome ofM. lepraewas first described and subsequently ...

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cis-regulatory variation modulates susceptibility to enteric infection in the Drosophila genetic reference panel

Michael Vincent Frochaux, Bart Deplancke, Dani Osman, Maroun Bou Sleiman, Tommaso Andreani, Riccardo Dainese, Virginie Sandra Braman, Vincent Roland Julien Gardeux, Maria Litovchenko, Brian Dennis Hollis

Background: Resistance to enteric pathogens is a complex trait at the crossroads of multiple biological processes. We have previously shown in the Drosophila Genetic Reference Panel (DGRP) that resistance to infection is highly heritable, but our understan ...

2020