Structural properties of pore-forming oligomers of alpha-synuclein

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Background: Patients suffering from functional neurological disorder (FND) experience disabling neurological symptoms not caused by an underlying classical neurological disease (such as stroke or multiple sclerosis). The diagnosis is made based on reliable ...

Single-molecule imaging methods are of importance in structural biology, and specifically in the imaging of proteins, since they can elucidate conformational variability and structural changes that might be lost in imaging methods relying on averaging proc ...

Design exploration consists in browsing the design space and through the incremental generation of diverse design candidates increases creativity and diversity. When integrated into the early stages of the structural design process, the task is expected to ...

Huntington’s disease is a neurodegenerative dis- order caused by the expansion of a polyglutamine repeat (>36Q) in the N-terminal domain of the huntingtin protein (Htt), which renders the protein or fragments thereof more prone to aggregate and form inclus ...

Tensegrity structures have been widely utilized as lightweight structures due to their high stiffness-to-mass and strength-to-mass ratios. Minimal mass design of tensegrity structures subject to external loads and specific constraints (e.g., member yieldin ...

Lewy bodies (LBs) are α-synuclein (α-syn)-rich intracellular inclusions that are an important pathological hallmark of Parkinson disease and several other neurodegenerative diseases. Increasing evidence suggests that the aggregation of α-syn has a central ...

BackgroundTo assess the performance of plasma neurofilament light (NfL) and phosphorylated tau 181 (p-tau181) to inform about cerebral Alzheimer's disease (AD) pathology and predict clinical progression in a memory clinic setting.MethodsPlasma NfL and p-ta ...

The immediate application of research discoveries requires a global and exact understanding of the structure under consideration. To gain insight into the complex behavior of structures, numerical simulations are carried out in parallel to physical experim ...

Lewy bodies (LBs), one of the neuropathological defining hallmarks of Parkinson's disease (PD), are composed of a complex mixture of alpha-synuclein (aSyn) filaments and hundreds of proteins, lipids, and membranous organelles. However, these proteins' role ...

Loss of mitochondrial function and proteostasis typify aging and age-associated degenerative disorders such as Alzheimer's disease and muscle aging. To date, no cure or preventive measure is available to manage these conditions. Alterations of cellular pro ...

Numerical models of structural components that deteriorate primarily due to geometric instabilities under multiaxis cyclic loading are sensitive to both the assumed geometric imperfections and the nonlinear material model assumptions. Therefore, the accura ...

Design and verification of structures in modern codes of practice account for a safety format, ensuring that the probability of failure does not exceed a given threshold. Although specific safety formats are proposed in some cases for special types of stru ...

In diseases called tauopathies, misfolded tau proteins form aggregates called fibrils. Fibrils from nine different tauopathies show that tau misfolds in many ways, enabling the diseases to be classified according to fibril structure. ...

Numerical models that can simulate coupled geometric instabilities in steel beam-columns are required for the seismic assessment of certain steel moment-resisting frames. Reliably simulating coupled instabilities requires that the steel material is precise ...

Structural engineers play an increasing role in ensuring the transition towards a more sustainable construction sector: a) they are responsible for the design of the most resource- and energy-intensive part of buildings and infrastructure, and b) they regu ...

Structural properties of pore-forming oligomers of alpha-synuclein

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Multi-centre classification of functional neurological disorders based on resting-state functional connectivity

Amplitude and phase reconstruction for Low-Energy Electron Holography of individual proteins

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A New Chemoenzymatic Semisynthetic Approach Provides Insight into the Role of Phosphorylation beyond Exon1 of Huntingtin and Reveals N-Terminal Fragment Length-Dependent Distinct Mechanisms of Aggregation

Minimal mass design of active tensegrity structures

Reverse engineering Lewy bodies: how far have we come and how far can we go?

Plasma neurofilament light and phosphorylated tau 181 as biomarkers of Alzheimer's disease pathology and clinical disease progression

Structural design methodology in Integrally-Attached Timber Plate structures

Lewy body-associated proteins: Victims, instigators, or innocent bystanders? The case of AIMP2 and alpha-synuclein

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Structural strains of misfolded tau protein define different diseases

Reduced-order Models for Simulating Coupled Geometric Instabilities in Steel Beam-columns Under Inelastic Cyclic Straining

Component reuse in structural design: emerging practices and tools for the circular economy