Broad-Band Ultraviolet CD Spectroscopy of Ultrafast Peptide Backbone Conformational Dynamics

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The field of protein design has made remarkable progress over the past decade. Historically, the low reliability of purely structure-based design methods limited their application, but recent strategies that combine structure-based and sequence-based calcu ...

We report the nonreciprocal excitation of propagating forward volume exchange spin waves in yttrium iron garnet (YIG) thin film with perpendicular anisotropy by bringing the in-plane magnetization of Co20Fe60B20 (CoFeB) nanowires to resonance. All-electric ...

We investigate the gas-phase structure of the neutral pentaalanine peptide. The IR spectrum in the 340-1820 cm-1 frequency range is obtained by employing supersonic jet cooling, infrared multiphoton dissociation, and vacuum-ultraviolet action spectroscopy. ...

Engineering protein biosensors that sensitively respond to specific biomolecules by triggering precise cellular responses is a major goal of diagnostics and synthetic cell biology. Previous biosensor designs have largely relied on binding structurally well ...

Many future fusion devices will rely heavily, if not solely, on electron cyclotron (EC) heating subsystems to provide bulk heating, instability control (neoclassical tearing mode (NTM) stabilization), and thermal instability control. Efficient use of the i ...

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Chirality (C) is a fundamental property of objects, in terms of symmetry. It is extremely important to sense and distinguish chiral molecules in the fields of biochemistry, science, and medicine. Vibrational circular dichroism (VCD) spectroscopy, obtained ...

Solving native structures of such large molecules, like biomolecules, is often challenging, particularly due to the potentially infinite number of non-covalent interactions with water. In this thesis, we report the use of cold ion gas-phase action spectros ...

We review three different approaches for the calculation of electromagnetic multipoles, namely, the Cartesian primitive multipoles, the Cartesian irreducible multipoles, and the spherical multipoles. We identify the latter as the best suited to describe th ...

We report on the C K-edge x-ray absorption spectra and the resonant (RXES) and non-resonant (NXES) x-ray emission spectra of ethylene, allene and butadiene in the gas phase. The RXES and NXES show clear differences for the different molecules. Overall both ...

Following the hugely successful application of deep learning methods to protein structure prediction, an increasing number of design methods seek to leverage generative models to design proteins with improved functionality over native proteins or novel str ...

The new trends for anomalous Nernst effect (ANE)-based thermoelectric devices require materials with large ANE values to realize the scalable generation of voltage. Recently, very large ANE values have been observed in single crystals of some novel magneti ...

Chirality is a structural property of molecules lacking mirror symmetry that has strong implications in diverse fields, ranging from life sciences to materials science. Chirality-sensitive spectroscopic methods, such as circular dichroism, exhibit weak sig ...

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The accurate identification of the three-dimensional quantitative shape of a cell nucleus is now possible without fluorescent staining by applying computational segmentation to refractive index tomograms recorded in the flow cytometry mode. ...

Single-molecule imaging methods are of importance in structural biology, and specifically in the imaging of proteins, since they can elucidate conformational variability and structural changes that might be lost in imaging methods relying on averaging proc ...

Imaging of proteins at the single-molecule level can reveal conformational variability, which is essential for the understanding of biomolecules. To this end, a biologically relevant state of the sample must be retained during both sample preparation and i ...

Biochemistry, ecology, and neuroscience are examples of prominent fields aiming at describing interacting systems that exhibit nontrivial couplings to complex, ever-changing environments. We have recently shown that linear interactions and a switching envi ...

Broad-Band Ultraviolet CD Spectroscopy of Ultrafast Peptide Backbone Conformational Dynamics

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From Sequence to Dynamics to Function: Computational Design of Allostery and Ligand Selectivity in G-Protein Coupled Receptors

Development of tools and methods for protein identification: From single molecules to in vivo applications

Opportunities and challenges in design and optimization of protein function

Reconfigurable nonreciprocal excitation of propagating exchange spin waves in perpendicularly magnetized yttrium iron garnet thin films

Indication of 310-Helix Structure in Gas-Phase Neutral Pentaalanine

Computational design of dynamic receptor—peptide signaling complexes applied to chemotaxis

High power mm-wave loss measurements of ITER ex-vessel waveguide components at the FALCON test facility at the Swiss Plasma Center

Global 'zero particle flux-driven' gyrokinetic analysis of the density profile for a TCV plasma

Dielectric Tetramer Nanoresonators Supporting Strong Superchiral Fields for Vibrational Circular Dichroism Spectroscopy

Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy

Multipolar expansions for scattering and optical force calculations beyond the long wavelength approximation

Carbon K-edge x-ray emission spectroscopy of gas phase ethylenic molecules

Deep learning approaches for conformational flexibility and switching properties in protein design

Large Anomalous Nernst Angle in Co2MnGa Thin Film

Hard X-ray helical dichroism of disordered molecular media

Ultrafast carrier and quasiparticle dynamics in strongly confined perovskite nanoplatelets

Stain-free identification of cell nuclei using tomographic phase microscopy in flow cytometry

Amplitude and phase reconstruction for Low-Energy Electron Holography of individual proteins

Low-energy electron holography imaging of conformational variability of single-antibody molecules from electrospray ion beam deposition

Mutual information in changing environments: Nonlinear interactions, out-of-equilibrium systems, and continuously varying diffusivities