A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

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BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

Long-range axons are fundamental to brain connectivity and functional organization, enabling communication between different brain regions. Recent advances in experimental techniques have yielded a substantial number of whole-brain axonal reconstructions. ...

Background: Clinical and translational research has identified deficits in the dopaminergic neurotransmission in the striatum in Alzheimer's disease (AD) and this could be related to the pathophysiology of psychiatric symptoms appearing even at early stage ...

Aging populations face significant cognitive challenges, particularly in working memory (WM). Transcranial alternating current stimulation (tACS) offer promising avenues for cognitive enhancement, especially when inspired by brain physiology. This study (N ...

Recent advancements in neuroscience, wearable technology, and artificial intelligence are paving the way for computing systems that are integrated with the brain and nervous system. Over the past years, we have witnessed the simultaneous progression of wea ...

The functional complexity of brain circuits underlies the broad spectrum of behaviors, cognitive functions, and their associated disorders. Mitochondria, traditionally known for their role in cellular energy metabolism, are increasingly recognized as centr ...

Discovering principles underlying the control of animal behavior requires a tight dialogue between experiments and neuromechanical models. Such models have primarily been used to investigate motor control with less emphasis on how the brain and motor syste ...

The process of quantifying and analyzing animal behavior involves translating the naturally occurring descriptive language of their actions into machine-readable code. Yet, codifying behavior analysis is often challenging without deep understanding of anim ...

In Parkinson's disease, pathogenic factors such as the intraneuronal accumulation of the protein alpha-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtype ...

The human brain has evolved to predict and anticipate environmental events from their temporal dynamics. Predictions can bias perception toward the recent past, particularly when the environment contains no foreseeable changes, but can also push perception ...

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

Gyrification of the cerebral cortex is a developmentally important process, but the mechanisms that drive cortical folding are not fully known. Theories propose that changes within the cortical plate (CP) cause gyrification, yet differences between the CP ...

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of alpha-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants link ...

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

Chattez avec Graph Search

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

Computational Generation of Long-range Axonal Morphologies

Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement

NeuroCHI: Are We Prepared for the Integration of the Brain with Computing?

The Emerging Role of Brain Mitochondria in Fear and Anxiety

The brain’s go-getter circuit: Anterior cingulate cortex to nucleus accumbens and its disruption by stress

NeuroMechFly v2: simulating embodied sensorimotor control in adult Drosophila

Commentary: Alpha(1)-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

AmadeusGPT: a natural language interface for interactive animal behavioral analysis

Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

Serial dependence and representational momentum in single-trial perceptual decisions

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Genetic and microstructural differences in the cortical plate of gyri and sulci during gyrification in fetal sheep

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

Implantable probe for stimulating neurological target e.g. neurons and subthalamic nucleus, has several microelectrode elements arranged at distal end of elongated probe shaft, and electrical contact arranged proximally along shaft