Response to Comment on "Restoring Voluntary Control of Locomotion After Paralyzing Spinal Cord Injury"

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Reinforcement feedback can improve motor learning, but the underlying brain mechanisms remain underexplored. In particular, the causal contribution of specific patterns of oscillatory activity within the human striatum is unknown. To address this question, ...

Animal locomotion is the result of complex and multi-layered interactions between the nervous system, the musculo-skeletal system and the environment. Decoding the underlying mechanisms requires an integrative approach. Comparative experimental biology has ...

Locomotion is based on a sophisticated interaction among the environment, the musculoskeletal system, the spinal cord, and the brain locomotor areas. Quality of life is strongly related to the proper capability of this movement. However, many pathologies, ...

Quadruped animal locomotion emerges from the interactions between the spinal central pattern generator (CPG), sensory feedback, and supraspinal drive signals from the brain. Computational models of CPGs have been widely used for investigating the spinal co ...

Objective. Studying the neural components regulating movement in human locomotion is obstructed by the inability to perform invasive experimental recording in the human neural circuits. Neuromechanical simulations can provide insights by modeling the locom ...

Locomotion is an essential evolutive innovation of living beings that allows them to colonize and dominate the planet. As diverse as animal morphologies are (living) and were (extinct), their locomotion modalities are also diverse. In particular, animal mo ...

Robotics and neuroscience are sister disciplines that both aim to understand how agile, efficient, and robust locomotion can be achieved in autonomous agents. Robotics has already benefitted from neuromechanical principles discovered by investigating anima ...

The transition from aquatic to terrestrial environments represents a significant event in the history of evolution. For this transition to occur, animals had to adapt their morphology, physiology and locomotory skills to handle the challenges and interacti ...

Spinal Cord Injury (SCI) affects almost 500,000 people every year, causing complete paralysis of both legs in severe cases, with no current treatment perspective. However, new neuroengineering technologies, such as the Brain Spine Interface (BSI), have eme ...

Spinal-cord injury interrupts communication between the brain and spinal cord, leading to paralysis. An implant that decodes the brain signals that control movements and drives electrical stimulation of the spinal cord re-establishes this communication, en ...

The spinal cord is an elongated nervous structure that together with the brain forms the central nervous system. It relays sensory and motor information between the brain and the body, thus controlling most somatic and autonomic body functions. In recent y ...

Recent years have seen considerable progress in understanding brain function, and in modulating it through real-time fMRI neurofeedback (NF). Inspired by these advances, paired with the unique possibility of inducing the clinically relevant Presence Halluc ...

A spinal cord injury interrupts the communication between the brain and the region of the spinal cord that produces walking, leading to paralysis(1,2). Here, we restored this communication with a digital bridge between the brain and spinal cord that enable ...

Background All behaviour requires energy, and measuring energy expenditure in standard units (joules) is key to linking behaviour to ecological processes. Animal-borne accelerometers are commonly used to infer proxies of energy expenditure, termed 'dynamic ...

Diffusion Magnetic Resonance Imaging (dMRI) is a powerful non-invasive method for studying white matter tracts of the brain. However, accurate microstructure estimation with fiber orientation distribution (FOD) using existing computational methods requires ...

A memory engram is thought to be the physical substrate of the memory trace within the brain, which is generally depicted as a neuronal ensemble activated by learning to fire together during encoding and retrieval. It has been postulated that engram cell e ...

The present invention relates to a combined neuromodulation and/or neurostimulation system (10) for mitigating locomotor deficits of/or neuronal disorders, especially Parkinson's disease, said system (10) comprising: - at least one Deep Brain Stimulation ( ...

The main theme of my thesis will be to use neuro-muscular modeling techniques to study locomotion of terrestrial mammals. Locomotion is the ability of animals to interact with the environment to propel themselves in space. It involves co-ordination and pre ...

In this paper, we present a novel control architecture for the online adaptation of bipedal locomotion on inclined obstacles. In particular, we introduce a novel, cost-effective, and versatile foot sensor to detect the proximity of the robot's feet to the ...

One of the most important goals in neuroscience research has always been to understand how animals control their behavior. However, the long focus on the role of brain neurons in behavioral control might be missing the full story. In fact, brain-wide fluct ...

Response to Comment on "Restoring Voluntary Control of Locomotion After Paralyzing Spinal Cord Injury"

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Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills

Integration of feedforward and feedback control in the neuromechanics of vertebrate locomotion: a review of experimental, simulation and robotic studies

Investigating the neuromechanical control of healthy gait modulation and pathological gaits observed in cerebral palsy using neuromuscular simulations

Puppeteer and Marionette: Learning Anticipatory Quadrupedal Locomotion Based on Interactions of a Central Pattern Generator and Supraspinal Drive

Investigating the roles of reflexes and central pattern generators in the control and modulation of human locomotion using a physiologically plausible neuromechanical model

Beyond undulation! Body morphology and sensing components of elongated animals and robots reveal skills to maintain competent locomotion

The neuromechanics of animal locomotion: From biology to robotics and back

Neuromechanical Simulations of Animats with Decentralised Control

Brain-controlled spinal cord stimulation to restore mobility after spinal cord injury

A digital bridge between brain and spinal cord restores walking after paralysis

Digital reconstruction of the mammalian spinal cord: from anatomical reference volume to cell type atlas of the mouse spinal cord

Neuroengineering of hallucinations through fMRI neurofeedback: Understanding and modulating neural dynamics for the control of hallucinations in health and disease

Walking naturally after spinal cord injury using a brain-spine interface

Combining accelerometry with allometry for estimating daily energy expenditure in joules when in-lab calibration is unavailable

Robust Estimation of the Microstructure of the Early Developing Brain Using Deep Learning

Tissue clearing applications in memory engram research

Neuromodulation/neurostimulation system for mitigating locomotor deficits of parkinson's disease, spinal cord injury (sci), stroke and/or other neurological disorders

A computational modeling approach to study the neuromechanics of terrestrial locomotion

Online Bipedal Locomotion Adaptation for Stepping on Obstacles Using a Novel Foot Sensor

Uncovering the neural encoding of behavior in the adult Drosophila motor system