Embryogenesis is a complex process that starts from a single-cell fertilised egg and ends with a completely formed embryo. During embryo development, tissues are formed, patterned, and matured to create a fully functional organism. Central to these process ...
Latest advances in super-resolution microscopy allow the study of subcellular features at the level of single proteins, which could lead to discoveries in fundamental biological processes, specifically in cell signaling mediated by membrane receptors. Desp ...
Centrioles are evolutionarily conserved microtubule-based organelles essential for cell division, ciliogenesis, and cell polarity. While centrioles are critical for many cellular processes, their selective elimination is crucial during specific development ...
Congenital myasthenic syndrome-22 (CMS22, OMIM 616224) is a rare genetic disorder caused by deleterious genetic variation in the prolyl endopeptidase-like (PREPL) gene. Previous reports have described patients with deletions and nonsense variants in PREPL, ...
Signaling centers are specialized groups of cells that release morphogens, guiding the fate and behavior of adjacent cells during morphogenesis. For instance, the apical-ectodermal-ridge (AER) in developing limbs, is crucial for coordinating cell fate and ...
Most traits are polygenic, and the contributing loci can be identified by genome-wide association studies. The genetic basis of adaptation (adaptive architecture) is, however, difficult to characterize. Here, we propose to study the adaptive architecture o ...
Our understanding of the composition and functions of splenic stromal cells remains incomplete. Here, based on analysis of over 20,000 single cell transcriptomes of splenic fibroblasts, we characterized the phenotypic and functional heterogeneity of these ...
