Publications associées à Impairment of hippocampal astrocyte-mediated striatal dopamine release and locomotion in Alzheimer's disease

Publications associées (16)

CEST imaging combined with 1H-MRS reveal the neuroprotective effects of riluzole by improving neurotransmitter imbalances in Alzheimer's disease mice

BackgroundThe imbalance of glutamate (Glu) and gamma-aminobutyric acid (GABA) neurotransmitter system plays a crucial role in the pathogenesis of Alzheimer's disease (AD). Riluzole is a Glu modulator originally approved for amyotrophic lateral sclerosis th ...

BMC2025

A posterior insula to lateral amygdala pathway transmits US-offset information with a limited role in fear learning

Ralf Schneggenburger, Olexiy Kochubey, Shriya Palchaudhuri, Denys Osypenko, Bei-Xuan Lin, Jinyun Wu

During fear learning, associations between a sensory cue (conditioned stimulus, CS) and an aversive stimulus (unconditioned stimulus, US) are formed in specific brain circuits. The lateral amygdala (LA) is involved in CS-US integration; however, US pathway ...

2025

Development of Small Molecule Heparin Glycomimetics for Applications in Nerve Regeneration Therapies

Melis Özkan

Heparin and heparan sulfate (HS) glycosaminoglycans (GAGs), essential components of the extracellular matrix (ECM), regulate a vast array of biological processes by modulating protein interactions and cellular signaling. Their structural complexity, driven ...

EPFL2025

Computational Generation of Long-range Axonal Morphologies

Henry Markram, Lida Kanari, Rémy Valentin Petkantchin, Adrien Berchet

Long-range axons are fundamental to brain connectivity and functional organization, enabling communication between different brain regions. Recent advances in experimental techniques have yielded a substantial number of whole-brain axonal reconstructions. ...

HUMANA PRESS INC2025

Physiology-inspired bifocal fronto-parietal tACS for working memory enhancement

Sylvain Jean-François Harquel, Pablo Maceira Elvira, Friedhelm Christoph Hummel, Traian Popa, Umberto Nencha

Aging populations face significant cognitive challenges, particularly in working memory (WM). Transcranial alternating current stimulation (tACS) offer promising avenues for cognitive enhancement, especially when inspired by brain physiology. This study (N ...

2024

The Emerging Role of Brain Mitochondria in Fear and Anxiety

Maria del Carmen Sandi Perez, Alessandro Chioino

The functional complexity of brain circuits underlies the broad spectrum of behaviors, cognitive functions, and their associated disorders. Mitochondria, traditionally known for their role in cellular energy metabolism, are increasingly recognized as centr ...

Springer Nature2024

A Multi-channel Stimulator with an Active Electrode Array Implant for Vagal-cardiac Neuromodulation Studies

Outman Akouissi

BackgroundImplantable vagus nerve stimulation is a promising approach for restoring autonomic cardiovascular functions after heart transplantation. For successful treatment a system should have multiple electrodes to deliver precise stimulation and complex ...

SPRINGERNATURE2024

NeuroCHI: Are We Prepared for the Integration of the Brain with Computing?

Olaf Blanke

Recent advancements in neuroscience, wearable technology, and artificial intelligence are paving the way for computing systems that are integrated with the brain and nervous system. Over the past years, we have witnessed the simultaneous progression of wea ...

ACM2024

Processing speed mediates the relationship between DDR1 and psychosocial functioning in euthymic patients with bipolar disorder presenting psychotic symptoms

Erick Jorge Canales Rodriguez

The DDR1 locus is associated with the diagnosis of schizophrenia and with processing speed in patients with schizophrenia and first-episode psychosis. Here, we investigated whether DDR1 variants are associated with bipolar disorder (BD) features. First, we ...

2024

Commentary: Alpha(1)-adrenergic receptor blockade in the ventral tegmental area attenuates acquisition of cocaine-induced pavlovian associative learning

Maria del Carmen Sandi Perez, Anna Lasne, Merkourios Simos

FRONTIERS MEDIA SA2023

Stable isotope labeling and ultra-high-resolution NanoSIMS imaging reveal alpha-synuclein-induced changes in neuronal metabolism in vivo

Bernard Schneider, Graham Knott, Bohumil Maco, Anders Meibom, Stéphane Laurent Escrig, Sofia Carmen Suzanne Spataro, Louise Helene Soegaard Jensen

In Parkinson's disease, pathogenic factors such as the intraneuronal accumulation of the protein alpha-synuclein affect key metabolic processes. New approaches are required to understand how metabolic dysregulations cause degeneration of vulnerable subtype ...

2023

Chronic recording of cortical activit y underlying vocalization in awake minipigs

Giuseppe Schiavone, Florian Dylan Fallegger, Stéphanie Lacour

Background: Investigating brain dynamics underlying vocal production in animals is a powerf u l w a y to inform on the neural bases of human speech. In particular, brain networks underlying vocal production in non-human primates show striking similarities ...

ELSEVIER2022

Digital Reconstruction of the Neuro-Glia-Vascular Architecture

Kathryn Hess Bellwald, Henry Markram, Felix Schürmann, Corrado Cali, Alexis Arnaudon, Daniel Keller, Marwan Muhammad Ahmed Abdellah, Lida Kanari, Eleftherios Zisis, Michael Emiel Gevaert, Benoît Jean-Albert Coste, Thomas Brice Delemontex, Alessandro Enrico Foni

Astrocytes connect the vasculature to neurons mediating the supply of nutrients and biochemicals. They are involved in a growing number of physiological and pathophysiological processes that result from biophysical, physiological, and molecular interaction ...

OXFORD UNIV PRESS INC2021

Common genetic variants associated with Parkinson's disease display widespread signature of epigenetic plasticity

Philipp Bucher, Giovanna Ambrosini

Parkinson disease (PD) is characterized by a pivotal progressive loss of substantia nigra dopaminergic neurons and aggregation of alpha-synuclein protein encoded by the SNCA gene. Genome-wide association studies identified almost 100 sequence variants link ...

Springer Nature2019

Implantable probe for stimulating neurological target e.g. neurons and subthalamic nucleus, has several microelectrode elements arranged at distal end of elongated probe shaft, and electrical contact arranged proximally along shaft

Philippe Renaud, André Mercanzini

Described herein are microelectrode array devices, and methods of fabrication and use of the same, to provide highly localized and efficient electrical stimulation of a neurological target. The device includes multiple microelectrode elements arranged alon ...

2010

Stress-induced cognitive and psychopathological alterations : functional involvement of the neural cell adhesion molecule (NCAM)

Maria del Carmen Sandi Perez

Intensive research over the past few years has provided evidence, that stress is a potent modulator of brain function and cognition. In particular cognitive and emotional processes have been shown to be susceptible to modulation by stress. Whereas acute st ...

EPFL2009