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This workshop is promoted by the “Indoor Air Quality and Health” scientific committee of the International Commission on Occupational Health (ICOH). Data from nationwide cross-sectional questionnaire survey, nested cross-sectional surveillance and one-year longitudinal study in modern office buildings will be presented. The workshop will focus on how the microclimatic conditions interplay with personal and occupational factors deteriorating ocular health, airway health, and work performance. A review of studies of individuals with severe intolerance will be presented to understand the mechanisms of this reactivity to the indoor environments. An integrated approach based on the recent evidence for risk assessment and specific indoor problem solving, through an integration of building assessment, questionnaire survey, and environmental measurements will be presented.