Publication

Molecular mechanisms governing Ca2+ regulation of evoked and spontaneous release

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Objective: Ultrasound (US) stimulation carries the promise of a selective, reversible, and non-invasive modulation of neural activity without the need for genetic manipulation of neural structures. However, the mechanisms of US-induced generation of action ...

IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC2020

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Cations influence the electrostatic, chemical and mechanical properties of lipid bilayers. Here, label-free second harmonic microscopy shows that cation-induced transient ordering of water also plays a role in driving membrane curvature fluctuations, linki ...

NATURE PUBLISHING GROUP2020

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Micro-nanotechnology based multielectrode arrays have led to remarkable progress in the field of transmembrane voltage recordings of excitable cells. However, electrode geometries alone have failed to produce a cell-electrode interface that is sufficiently ...

EPFL2020

GABA-mediated tonic inhibition differentially modulates gain in functional subtypes of cortical interneurons

Sean Lewis Hill, Christian Andreas Rössert, Bas-Jan Zandt, Steven Petrou

The binding of GABA (gamma-aminobutyric acid) to extrasynaptic GABA(A) receptors generates tonic inhibition that acts as a powerful modulator of cortical network activity. Despite GABA being present throughout the extracellular space of the brain, previous ...

National Academy of Sciences2020

Nanovolcano microelectrode arrays: toward long-term on-demand registration of transmembrane action potentials by controlled electroporation

Philippe Renaud, Arnaud Bertsch, Benoît Xavier Emmanuel Desbiolles, Nicolas Grégoire Maïno, Etienne de Coulon, Stephan Rohr

Volcano-shaped microelectrodes (nanovolcanoes) functionalized with nanopatterned self-assembled monolayers have recently been demonstrated to report cardiomyocyte action potentials after gaining spontaneous intracellular access. These nanovolcanoes exhibit ...

2020

Structures of three MORN repeat proteins and a re-evaluation of the proposed lipid-binding properties of MORN repeats

Charlotte Julie Caroline Gehin

MORN (Membrane Occupation and Recognition Nexus) repeat proteins have a wide taxonomic distribution, being found in both prokaryotes and eukaryotes. Despite this ubiquity, they remain poorly characterised at both a structural and a functional level compare ...

2020

Mammalian membrane trafficking as seen through the lens of bacterial toxins

Françoise Gisou van der Goot Grunberg, Oksana Andrei Sergeeva, Francisco De Magalhães Sarmento R De Mesquita

A fundamental question of eukaryotic cell biology is how membrane organelles are organised and interact with each other. Cell biologists address these questions by characterising the structural features of membrane compartments and the mechanisms that coor ...

WILEY2020

Calcium-triggered fusion of lipid membranes is enabled by amphiphilic nanoparticles

Francesco Stellacci, Zekiye Pelin Güven, Ye Yang, Ahmet Bekdemir

Lipid membrane fusion is an essential process for a number of critical biological functions. The overall process is thermodynamically favorable but faces multiple kinetic barriers along the way. Inspired by nature's engineered proteins such as SNAP recepto ...

National Academy of Sciences2020

Dynamic Imaging of Lipid Membranes by Means of Water

Orly Bagunu Tarun

Lipid membranes are self-assembled structures whose composition determines the properties of membranes of cells and organelles. The molecular level understanding of lipid membranes is based on spectroscopy and MD simulations of lipid monolayer systems. As ...

EPFL2019